Evidence map›Paper›PMID 35189266›Full record

ReviewAdvanced drug delivery reviews2022

Merging data curation and machine learning to improve nanomedicines.

Chen Chen, Zvi Yaari, Elana Apfelbaum, Piotr Grodzinski, Yosi Shamay, Daniel A Heller

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
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  3. Article
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  11. Article
  12. Machine Learning-Enhanced Nanoparticle Design for Precision Cancer Drug Delivery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  13. Article
  14. Review
  15. Review
  16. Machine Learning in Polymer Research.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  17. Review
  18. Machine learning in drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chen ChenMemorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Tri-institutional Ph.D. Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Zvi YaariMemorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Elana ApfelbaumDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA.
Piotr GrodzinskiNanodelivery Systems and Devices Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Yosi ShamayDepartment of Biomedical Engineering, Technion - Israel Institute of Technology, Haifa, Israel.
Daniel A HellerMemorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Tri-institutional Ph.D. Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA. Electronic address: hellerd@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
P-selectin-Mediated Targeting of PI3K Nanomedicines to the Tumor MicroenvironmentR01CA215719 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI HELLER, DANIEL ALAN · 2018 to 2022
$3.1M
Tumor-Selective Delivery Approaches for MedulloblastomaR01NS116353 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI HELLER, DANIEL ALAN, RAJU, PRAVEEN B. · 2020 to 2024
$3.1M
Nanotechnology as a therapeutic approach in arteriovenous fistula maturationR01DK129299 · NIDDK · UNIVERSITY OF UTAH · PI JAIMES, EDGAR A, SHIU, YAN-TING E. · 2021 to 2024
$1.7M
Renal tubule-specific nanotherapeutics for acute kidney injuryR01DK114321 · NIDDK · SLOAN-KETTERING INST CAN RESEARCH · PI HELLER, DANIEL ALAN, JAIMES, EDGAR A · 2018 to 2020
$796k
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA215719NIDDK NIH HHS R01 DK114321NIDDK NIH HHS R01 DK129299NINDS NIH HHS R01 NS116353
6 · The paper itself

Abstract

Nanomedicine design is often a trial-and-error process, and the optimization of formulations and in vivo properties requires tremendous benchwork. To expedite the nanomedicine research progress, data science is steadily gaining importance in the field of nanomedicine. Recently, efforts have explored the potential to predict nanomaterials synthesis and biological behaviors via advanced data analytics. Machine learning algorithms process large datasets to understand and predict various material properties in nanomedicine synthesis, pharmacologic parameters, and efficacy. "Big data" approaches may enable even larger advances, especially if researchers capitalize on data curation methods. However, the concomitant use of data curation processes needed to facilitate the acquisition and standardization of large, heterogeneous data sets, to support advanced data analytics methods such as machine learning has yet to be leveraged. Currently, data curation and data analytics areas of nanotechnology-focused data science, or 'nanoinformatics', have been proceeding largely independently. This review highlights the current efforts in both areas and the potential opportunities for coordination to advance the capabilities of data analytics in nanomedicine.

Indexed as

Data CurationNanomedicineAlgorithmsHumansMachine LearningNanotechnologyArtificial intelligenceCancer therapeuticsData curationNanoparticles, data miningNanotechnologyParticle characterization

Identifiers

PMID35189266
PMCPMC9233944

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.