Evidence map›Paper›PMID 35189037›Full record

ReviewAdvanced healthcare materials2022

Biopolymer-Based Multilayer Microparticles for Probiotic Delivery to Colon.

Sepehr Talebian, Timothy Schofield, Peter Valtchev, Aaron Schindeler, John M Kavanagh, Qayyum Adil, Fariba Dehghani

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced healthcare materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Sepehr TalebianSchool of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW, 2006, Australia.ORCID 0000-0002-4735-0986
Timothy SchofieldSchool of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW, 2006, Australia.
Peter ValtchevSchool of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW, 2006, Australia.ORCID 0000-0002-2622-5721
Aaron SchindelerSchool of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW, 2006, Australia.ORCID 0000-0002-7757-6281
John M KavanaghSchool of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW, 2006, Australia.ORCID 0000-0002-9129-1215
Qayyum AdilPharmaCare Laboratories, 18 Jubilee Ave, Warriewood, NSW, 2102, Australia.
Fariba DehghaniSchool of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW, 2006, Australia.ORCID 0000-0002-7805-8101
The University of Sydney · AUJubilee Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The potential health benefits of probiotics may not be realized because of the substantial reduction in their viability during food storage and gastrointestinal transit. Microencapsulation has been successfully utilized to improve the resistance of probiotics to critical conditions. Owing to the unique properties of biopolymers, they have been prevalently used for microencapsulation of probiotics. However, majority of microencapsulated products only contain a single layer of protection around probiotics, which is likely to be inferior to more sophisticated approaches. This review discusses emerging methods for the multilayer encapsulation of probiotic using biopolymers. Correlations are drawn between fabrication techniques and the resultant microparticle properties. Subsequently, multilayer microparticles are categorized based on their layer designs. Recent reports of specific biopolymeric formulations are examined regarding their physical and biological properties. In particular, animal models of gastrointestinal transit and disease are highlighted, with respect to trials of multilayer microencapsulated probiotics. To conclude, novel materials and approaches for fabrication of multilayer structures are highlighted.

Indexed as

ProbioticsAnimalsBiopolymersColonDrug CompoundingMicrobial ViabilityBiopolymerscolondrug deliveryhydrogelsmicroencapsulationprobiotics

Identifiers

PMID35189037
PMCPMC11468821
OpenAlexW4213140171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.