ArticleAngewandte Chemie (International ed. in English)2022
Synthesis of Enantiopure Sulfoxides by Concurrent Photocatalytic Oxidation and Biocatalytic Reduction.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 57 citations in OpenAlex.
- Nanomedicines and stroke: Advantages in chronic inflammation treatment and neural regeneration.Neural regeneration research · 2026Article
- Concurrent Linear Deracemization of Secondary Benzylic Alcohols via Simultaneous Photocatalysis and Whole-cell Biocatalysis.ACS catalysis · 2025Article
- Combining Photochemical Oxyfunctionalization and Enzymatic Catalysis for the Synthesis of Chiral Pyrrolidines and Azepanes.The Journal of organic chemistry · 2025Article
- Cooperative chemoenzymatic and biocatalytic cascades to access chiral sulfur compounds bearing C(spNature communications · 2024Article
- Characterization and mechanism investigation of salt-activated methionine sulfoxide reductase A from halophiles.iScience · 2024Article
- Transaminase-catalysis to produce trans-4-substituted cyclohexane-1-amines including a key intermediate towards cariprazine.Communications chemistry · 2024Article
- Enzymatic Resolution and Decarboxylative Functionalization of α-Sulfinyl Esters.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Article
- Photoexcited Ru single-atomic sites for efficient biomimetic redox catalysis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Photobiocatalytic Strategies for Organic Synthesis.Chemical reviews · 2023Review
- Discovery and Rational Mutagenesis of Methionine Sulfoxide Reductase Biocatalysts To Expand the Substrate Scope of the Kinetic Resolution of Chiral Sulfoxides.ACS catalysis · 2023Article
- Review
- Synthesis of Enantiopure Sulfoxides by Concurrent Photocatalytic Oxidation and Biocatalytic Reduction.Angewandte Chemie (International ed. in English) · 2022Article
- Synthesis of Enantiopure Sulfoxides by Concurrent Photocatalytic Oxidation and Biocatalytic Reduction.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
The concurrent operation of chemical and biocatalytic reactions in one pot is still a challenging task, and, in particular for chemical photocatalysts, examples besides simple cofactor recycling systems are rare. However, especially due to the complementary chemistry that the two fields of catalysis promote, their combination in one pot has the potential to unlock intriguing, unprecedented overall reactivities. Herein we demonstrate a concurrent biocatalytic reduction and photocatalytic oxidation process. Specifically, the enantioselective biocatalytic sulfoxide reduction using (S)-selective methionine sulfoxide reductases was coupled to an unselective light-dependent sulfoxidation. Protochlorophyllide was established as a new green photocatalyst for the sulfoxidation. Overall, a cyclic deracemization process to produce nonracemic sulfoxides was achieved and the target compounds were obtained with excellent conversions (up to 91 %) and superb optical purity (>99 % ee).
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