ArticleBrain : a journal of neurology2023
Network structure and transcriptomic vulnerability shape atrophy in frontotemporal dementia.
Article in Brain : a journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 83 citations in OpenAlex.
- Network-Based Spreading of Gray Matter Changes Across Different Stages of Psychosis.JAMA psychiatry · 2023Trial
- Temporal order of clinical, imaging, and biomarker changes in frontotemporal lobar degeneration-associated syndromes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Molecular, cellular and network mapping of brain structural deviations in patients with Post-COVID19 syndrome.Brain, behavior, & immunity - health · 2026Article
- Biological factors contributing to divergent cortical abnormalities in adolescent and adult psychiatric disorders.Translational psychiatry · 2026Article
- Global network and local vulnerabilities underlie brain atrophy across Parkinson's disease stages.Brain : a journal of neurology · 2026Article
- Cell-type and spatiotemporal transcriptional signatures of white matter morphometric similarity network alterations in major depressive disorder.Psychological medicine · 2026Article
- Emerging directions in tauopathy research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Structural connectome architecture and biological vulnerability shape cortical atrophy in cocaine use disorder.BMC medicine · 2026Article
- Structure-function coupling in the human brainstem.bioRxiv : the preprint server for biology · 2026Article
- Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer's disease.Research square · 2026Article
- Neurobiological mechanisms of electroconvulsive therapy in major depressive disorder: structure-function coupling with gene expression and molecular mechanism.Translational psychiatry · 2026Article
- Five energy metabolism pathways show distinct regional distributions and lifespan trajectories in the human brain.PLoS biology · 2026Article
- Associations of local white matter geometry with network efficiency, macrostructural abnormalities, and clinical severity in behavioural variant frontotemporal dementia.Brain communications · 2026Article
- Cortical morphometric gradients reveal molecular and cognitive underpinnings of bipolar disorder.Psychological medicine · 2025Article
- Quantifying brain atrophy in Frontotemporal Dementia: a head-to-head comparison of neuroimaging techniques.medRxiv : the preprint server for health sciences · 2025Article
- Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy.Nature communications · 2025Article
- Diffusion trajectory of atypical morphological development in autism spectrum disorder.Communications biology · 2025Article
- Network-dependent cortical thickness reductions following chronic methamphetamine use.Psychological medicine · 2025Article
- Cortical thickness subtypes in cognitively unimpaired individuals: Differential network and transcriptomic vulnerability to cortical thinning.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Reduced brain structural similarity is associated with maturation, neurobiological features, and clinical status in schizophrenia.Nature communications · 2025Article
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Authors and funding
35 authors at 20 institutions in 8 countries.
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Abstract
Connections among brain regions allow pathological perturbations to spread from a single source region to multiple regions. Patterns of neurodegeneration in multiple diseases, including behavioural variant of frontotemporal dementia (bvFTD), resemble the large-scale functional systems, but how bvFTD-related atrophy patterns relate to structural network organization remains unknown. Here we investigate whether neurodegeneration patterns in sporadic and genetic bvFTD are conditioned by connectome architecture. Regional atrophy patterns were estimated in both genetic bvFTD (75 patients, 247 controls) and sporadic bvFTD (70 patients, 123 controls). First, we identified distributed atrophy patterns in bvFTD, mainly targeting areas associated with the limbic intrinsic network and insular cytoarchitectonic class. Regional atrophy was significantly correlated with atrophy of structurally- and functionally-connected neighbours, demonstrating that network structure shapes atrophy patterns. The anterior insula was identified as the predominant group epicentre of brain atrophy using data-driven and simulation-based methods, with some secondary regions in frontal ventromedial and antero-medial temporal areas. We found that FTD-related genes, namely C9orf72 and TARDBP, confer local transcriptomic vulnerability to the disease, modulating the propagation of pathology through the connectome. Collectively, our results demonstrate that atrophy patterns in sporadic and genetic bvFTD are jointly shaped by global connectome architecture and local transcriptomic vulnerability, providing an explanation as to how heterogenous pathological entities can lead to the same clinical syndrome.
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Registered trials
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