Evidence map›Paper›PMID 35188868›Full record

ArticleGut microbes

The potential of fecal microbiota and amino acids to detect and monitor patients with adenoma.

Sofie Bosch, Animesh Acharjee, Mohammed N Quraishi, Patricia Rojas, Abdellatif Bakkali, Erwin Ew Jansen, Marina Brizzio Brentar, Johan Kuijvenhoven, Pieter Stokkers, Eduard Struys and 4 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Faecal amino acids stability: investigating optimal sampling conditions for analysis.Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Gut microbiota in colorectal cancer development and therapy.Nature reviews. Clinical oncology · 2023
    Review
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 5 countries.

Sofie BoschAmsterdam Umc, Vu University Medical Center, Department of Gastroenterology and Hepatology, Ag&m Research Institute, Amsterdam, The Netherlands.ORCID 0000-0001-9202-1674
Animesh AcharjeeCollege of Medical and Dental Sciences, Institute of Cancer and Genomic Sciences, Center for Computational Biology, University of Birmingham, UK.
Mohammed N QuraishiDepartment of Gastroenterology, University Hospitals Birmingham Nhs Foundation Trust, Birmingham, UK.
Patricia RojasInstitute of Applied Health Research, University of Birmingham, UK.
Abdellatif BakkaliDepartment of Clinical Chemistry, Vu University Medical Center, Amsterdam, The Netherlands.
Erwin Ew JansenDepartment of Clinical Chemistry, Vu University Medical Center, Amsterdam, The Netherlands.
Marina Brizzio BrentarAmsterdam Umc, Vu University Medical Center, Department of Gastroenterology and Hepatology, Ag&m Research Institute, Amsterdam, The Netherlands.
Johan KuijvenhovenSpaarne Gasthuis, Department of Gastroenterology and Hepatology, Spaarne Gasthuis (primary institute), Hoofddorp and Haarlem, The Netherlands.
Pieter StokkersOlvg West, Department of Gastroenterology and Hepatology, Onze Lieve Vrouwe Gasthuis West, Amsterdam, The Netherlands.
Eduard StruysDepartment of Clinical Chemistry, Vu University Medical Center, Amsterdam, The Netherlands.
Andrew D BeggsInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.ORCID 0000-0003-0784-2967
Georgios V GkoutosCollege of Medical and Dental Sciences, Institute of Cancer and Genomic Sciences, Center for Computational Biology, University of Birmingham, UK.
Tim Gj de MeijAmsterdam Umc, Vu University Amsterdam, Department of Paediatric Gastroenterology, Ag&m Research Institute, Amsterdam, The Netherlands.
Nanne Kh de BoerAmsterdam Umc, Vu University Medical Center, Department of Gastroenterology and Hepatology, Ag&m Research Institute, Amsterdam, The Netherlands.
Institute of Aging · CAAmsterdam UMC Location Vrije Universiteit Amsterdam · NLUniversity Hospitals Birmingham NHS Foundation Trust · GBUniversity of Birmingham · GBOLVG · NLSpaarne Ziekenhuis · NL

Funding

Cancer Research UK C31641/A23923
6 · The paper itself

Abstract

The risk of recurrent dysplastic colonic lesions is increased following polypectomy. Yield of endoscopic surveillance after adenoma removal is low, while interval colorectal cancers occur. To longitudinally assess the dynamics of fecal microbiota and amino acids in the presence of adenomatous lesions and after their endoscopic removal. In this longitudinal case-control study, patients collected fecal samples prior to bowel preparation before scheduled colonoscopy and 3 months after this intervention. Based on colonoscopy outcomes, patients with advanced adenomas and nonadvanced adenomas (0.5-1.0 cm) who underwent polypectomy during endoscopy (

Indexed as

AdenomaColorectal NeoplasmsGastrointestinal MicrobiomeAmino AcidsCase-Control StudiesHumansRisk FactorsAmino Acidsadenomabiomarkercolorectal cancerOmicssurveillance

Identifiers

PMID35188868
PMCPMC8865277
OpenAlexW4213199348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.