Evidence map›Paper›PMID 35188604›Full record

ArticleClinical rheumatology2022

Analysis of WDFY4 rs7097397 and PHLDB1 rs7389 polymorphisms in Chinese patients with systemic lupus erythematosus.

Jianzhao Zhai, Ping Zhang, Naidan Zhang, Yubin Luo, Yongkang Wu

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Article in Clinical rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Jianzhao ZhaiWest China School of Medicine/Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu, China.
Ping ZhangWest China School of Medicine/Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu, China.
Naidan ZhangWest China School of Medicine/Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu, China.
Yubin LuoDepartment of Rheumatology & Immunology, West China Hospital of Sichuan University, Chengdu, China.
Yongkang WuOutpatient Department, West China Hospital of Sichuan University, Chengdu, China. vipwyk@163.com.ORCID http://orcid.org/0000-0002-7352-3465

Funding

1·3·5 project for disciplines of excellence-clinical research incubation project, west china hospital, sichuan university 2020HXFH038project of science and technology bureau of chengdu 2019-GH02-00006-HZproject of science and technology bureau of chengdu 2019-YF05-00463-SNproject of science and technology department of sichuan 2020YFS0125
6 · The paper itself

Abstract

objectivesTo explore the relationship among patient-specific SNPs from one SLE family, lupus susceptibility, and laboratory indicators in a western Chinese population.

methodsWe previously performed whole exome sequencing in one SLE family and screened 5 SLE candidate SNPs. In this study, we verified them in 634 SLE patients and 400 healthy controls and analyzed the relationship between SNPs and laboratory indicators.

resultsAmong the 5 candidate SNPs, PHLDB1 rs7389T/G (dominant model, OR = 0.627, 95%CI = 0.480-0.820, P = 0.001) and WDFY4 rs7097397G/A (dominant model, OR = 0.653, 95%CI = 0.438-0.973, P = 0.035) were associated with SLE susceptibility. In addition, the G allele of rs7389 was related to an increased level of TNF-α (q = 0.013). The A allele of rs7097397 was related to reduced levels of IL-1β (q = 0.033) and IL-6 (q = 0.039) and high positive rate of antinuclear antibodies (q = 0.021).

conclusionsOur study indicated that both the rs7389T/G and rs7097397G/A polymorphisms were related to SLE susceptibility in western China. rs7389T/G was related to increased TNF-α content, while rs7097397G/A was associated with reduced IL-1β and IL-6 content and increased antinuclear antibody positive rate. Key Points • The G allele of rs7389 was related to reduced susceptibility to SLE. • The A allele of rs7097397 was associated with reduced susceptibility to SLE. • The G allele of rs7389 was related to increased levels of TNF-α. • The A allele of rs7097397 was related to decreased concentrations of IL-1β and IL-6, as well as an increased positive rate of antinuclear antibody.

Indexed as

Genetic Predisposition to DiseaseIntracellular Signaling Peptides and ProteinsLupus Erythematosus, SystemicNerve Tissue ProteinsAntibodies, AntinuclearAsian PeopleCase-Control StudiesChinaGene FrequencyHumansInterleukin-6Polymorphism, Single NucleotideTumor Necrosis Factor-alphaAntibodies, AntinuclearInterleukin-6Intracellular Signaling Peptides and ProteinsNerve Tissue ProteinsPHLDB1 protein, humanTumor Necrosis Factor-alphaWDFY4 protein, humanPHLDB1Single nucleotide polymorphismSystemic lupus erythematosusWDFY4

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PMID35188604

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