Evidence map›Paper›PMID 35188458›Full record

ArticleeLife2022

Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages.

Noella Lopes, Nicolas Boucherit, Jérémy C Santamaria, Nathan Provin, Jonathan Charaix, Pierre Ferrier, Matthieu Giraud, Magali Irla

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Basic interactions responsible for thymus function explain the convoluted medulla shape.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Review
  6. Assembling the thymus medulla: Development and function of epithelial cell heterogeneity.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Article
  7. Review
  8. Article
  9. Investigating Thymic Epithelial Cell Diversity Using Systems Biology.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Review
  10. Review
  11. Recirculating Foxp3Cellular and molecular life sciences : CMLS · 2022
    Article
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Noella LopesAix-Marseille University, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France.ORCID 0000-0002-6296-8426
Nicolas Boucherit *Aix-Marseille University, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
Jérémy C Santamaria *Aix-Marseille University, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France.ORCID 0000-0001-7613-3668
Nathan Provin *Nantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France.
Jonathan CharaixAix-Marseille University, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
Pierre FerrierAix-Marseille University, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
Matthieu GiraudNantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France.ORCID 0000-0002-1208-9677
Magali IrlaAix-Marseille University, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France.ORCID 0000-0001-8803-9708
Inserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interactions of developing T cells with Aire

Indexed as

Thymus GlandAnimalsAutoantigensCD4-Positive T-LymphocytesDNA-Binding ProteinsEpithelial CellsEpitheliumFemaleGene Expression ProfilingGene Expression RegulationHistonesMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicAutoantigensDNA-Binding ProteinsHistonesNerve Tissue ProteinsRag2 protein, mouseZfp312 protein, mousecellular crosstalkimmunologyinflammationmedullary thymic epithelial cellsmouseT cellsthymustolerance

Identifiers

PMID35188458
PMCPMC8860447
OpenAlexW4220734210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.