ArticleMicrobial genomics2022
An inventory of early branch points in microbial phosphonate biosynthesis.
Article in Microbial genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 12 citations in OpenAlex.
- From Discovery to Manufacturing: A Quantitative Review of Phosphonates and Strategies for High-Titer Production.Microorganisms · 2026Review
- Discovery of the Phosphonate Flavophos Produced byJournal of the American Chemical Society · 2026Article
- Discovery of the Phosphonate Flavophos Produced bybioRxiv : the preprint server for biology · 2026Article
- Genomic context analysis enables the discovery of an unusual NAD-dependent racemase in phosphonate catabolism.The FEBS journal · 2025Article
- Application of a replicative targetable vector system for difficult-to-manipulate streptomycetes.Applied microbiology and biotechnology · 2025Article
- Timing the evolution of phosphorus-cycling enzymes through geological time using phylogenomics.Nature communications · 2024Article
- Discovery of a glyphosate oxidase in nature.FEMS microbiology letters · 2024Article
- Deciphering the role of recurrent FAD-dependent enzymes in bacterial phosphonate catabolism.iScience · 2023Article
- The Microbial Degradation of Natural and Anthropogenic Phosphonates.Molecules (Basel, Switzerland) · 2023Review
- Advances in the Synthesis and Analysis of Biologically Active Phosphometabolites.International journal of molecular sciences · 2023Review
- 2-Aminoethylphosphonate utilization in Pseudomonas putida BIRD-1 is controlled by multiple master regulators.Environmental microbiology · 2022Article
- Evaluating Serpentinization as a Source of Phosphite to Microbial Communities in Hydrothermal Vents.GeobiologyArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial phosphonate biosynthetic machinery has been identified in ~5 % of bacterial genomes and encodes natural products like fosfomycin as well as cell surface decorations. Almost all biological phosphonates originate from the rearrangement of phosphoenolpyruvate (PEP) to phosphonopyruvate (PnPy) catalysed by PEP mutase (Ppm), and PnPy is often converted to phosphonoacetaldehyde (PnAA) by PnPy decarboxylase (Ppd). Seven enzymes are known or likely to act on either PnPy or PnAA as early branch points en route to diverse biosynthetic outcomes, and these enzymes may be broadly classified into three reaction types: hydride transfer, aminotransfer, and carbon-carbon bond formation. However, the relative abundance of these branch points in microbial phosphonate biosynthesis is unknown. Also unknown is the proportion of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.