Evidence map›Paper›PMID 35188449›Full record

ArticleCell cycle (Georgetown, Tex.)2022

LncRNA LINC00649 promotes the growth and metastasis of triple-negative breast cancer by maintaining the stability of HIF-1α through the NF90/NF45 complex.

Jianhua Zhang, Chuang Du, Linfeng Zhang, Yan Wang, Yingying Zhang, Jingruo Li

Open access · bronzeAbstract read
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
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  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Hypoxia-driven ncRNAs in breast cancer.Frontiers in oncology · 2023
    Review
  12. The Polyvalent Role of NF90 in RNA Biology.International journal of molecular sciences · 2022
    Review
  13. Review
  14. Article
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jianhua ZhangDepartment of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Chuang DuDepartment of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Linfeng ZhangDepartment of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Yan WangDepartment of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Yingying ZhangDepartment of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Jingruo LiDepartment of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Henan, China.
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is no clear treatment guideline or individualized treatment plan for triple-negative breast cancer (TNBC). The aim of this study was to investigate more effective targets for TNBC-targeted therapy. MDA-MB-231 and BT549 cell lines were used to explore the function of LINC00649 on the proliferation, invasion, and migration of TNBC cells. A mice subcutaneous tumor model and a pulmonary metastasis model was established to identify the role of LINC00649 on the growth and metastasis of TNBC

Indexed as

RNA, Long NoncodingTriple Negative Breast NeoplasmsAnimalsCell Line, TumorCell ProliferationHumansHypoxia-Inducible Factor 1, alpha SubunitMiceNuclear Factor 90 ProteinsHIF1A protein, humanHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitNuclear Factor 90 ProteinsRNA, Long NoncodingHIF-1αlncRNA LINC00649NF90/NF45Triple-negative breast cancer

Identifiers

PMID35188449
PMCPMC9037445
OpenAlexW4212844686

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.