ArticleMolecular systems biology2022
Is the kinetome conserved?
Article in Molecular systems biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The Dawn of High-Throughput and Genome-Scale Kinetic Modeling: Recent Advances and Future Directions.ACS synthetic biology · 2025Review
- Kinetic modules are sources of concentration robustness in biochemical networks.Science advances · 2025Article
- RBC-GEM: A genome-scale metabolic model for systems biology of the human red blood cell.PLoS computational biology · 2025Article
- A framework towards digital twins for type 2 diabetes.Frontiers in digital health · 2024Article
- Whole-genome sequences from wild-type and laboratory-evolved strains define the alleleome and establish its hallmarks.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Novel context-specific genome-scale modelling explores the potential of triacylglycerol production by Chlamydomonas reinhardtii.Microbial cell factories · 2023Article
- Prediction of metabolite-protein interactions based on integration of machine learning and constraint-based modeling.Bioinformatics advances · 2023Article
- MLAGO: machine learning-aided global optimization for Michaelis constant estimation of kinetic modeling.BMC bioinformatics · 2022Article
- Is the kinetome conserved?Molecular systems biology · 2022Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Computational biologists have labored for decades to produce kinetic models to mechanistically explain complex metabolic phenomena. The estimation of numerical values for the large number of kinetic parameters required for constructing large-scale models has been a major challenge. This collection of kinetic constants has recently been termed the kinetome (Nilsson et al, 2017). In this Commentary, we discuss the recent advances in the field that suggest that the kinetome may be more conserved than expected. A conserved kinetome will accelerate the development of future kinetic models of integrated cellular functions and expand their scope and usability in many fields of biology and biomedicine.
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