ArticleAddiction (Abingdon, England)2022
Trajectories of alcohol consumption in relation to all-cause mortality in patients with cardiovascular disease: a 35-year prospective cohort study.
Article in Addiction (Abingdon, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Article
- Insights Into Cardiovascular Disease in Women From the Framingham Heart Study.JACC. Advances · 2026Article
- Running from Death: Can Fitness Outpace Alcohol's Harm? Changes in Alcohol Intake, Fitness and All-Cause Mortality in the HUNT Study, Norway.Sports medicine (Auckland, N.Z.) · 2026Article
- Alcohol Consumption and Acute Coronary Syndrome: Epidemiology, Pathophysiology, and Clinical Perspectives.Journal of clinical medicine · 2025Review
- Changes in adiposity indices over 10 years and risk of type 2 diabetes: The Whitehall II cohort study.Diabetes, obesity & metabolism · 2025Article
- Which adiposity index is best? Comparison of five indicators and their ability to identify type 2 diabetes risk in a population study.Diabetes research and clinical practice · 2025Article
- Alcohol consumption trajectories and risk of breast cancer among postmenopausal women: a Danish cohort study.European journal of epidemiology · 2024Article
- Cognition of diet quality and dietary management in elderly patients with coronary and other atherosclerotic vascular disease in western China, a qualitative research study.BMC geriatrics · 2024Article
- A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals.EBioMedicine · 2024Article
- Trajectories of alcohol consumption in relation to all-cause mortality in patients with cardiovascular disease: a 35-year prospective cohort study.Addiction (Abingdon, England) · 2022Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsResearch into alcohol consumption and cardiovascular disease (CVD) patients' prognosis has largely ignored the longitudinal dynamics in drinking behaviour. This study measured the association between alcohol consumption trajectories and mortality risk in CVD patients.
designProspective cohort study.
settingUK-based Whitehall II Study.
participantsA total of 1306 participants with incident non-fatal CVD (coronary heart disease/stroke) events. MEASUREMENTS: Up to eight repeated measures of alcohol intake were available for each patient from the most recent assessment phase pre-incident CVD and all subsequent phases post-incident CVD, spanning up to three decades. Six trajectory groups of alcohol consumption were identified using group-based trajectory modelling and related to the risk of all-cause mortality, adjusting for demographics and changes in life-style and health status.
findingsThree hundred and eighty deaths were recorded during a median follow-up of 5 years after patients' last alcohol assessment. Compared with patients who consistently drank moderately (≤ 14 units/week), former drinkers had a greater risk of mortality (hazard ratio = 1.74, 95% confidence interval = 1.19-2.54) after adjustment for covariates. There was no significantly increased risk of mortality in long-term abstainers, reduced moderate drinkers, stable or unstable heavy drinkers. Cross-sectional analyses based only on drinking information at patients' last assessment found no significant differences in mortality risk for abstainers, former or heavy drinkers versus moderate drinkers.
conclusionsCardiovascular disease patients who consistently drink ≤ 14 units/week appear to have a similar risk of mortality to those who are long-term abstainers, which does not support a protective effect of moderate drinking on total mortality. Cardiovascular disease patients who stop drinking appear to have increased mortality risk compared with continuous moderate drinkers, but this may be linked to poor self-rated health before cardiovascular disease onset.
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