Evidence map›Paper›PMID 35188070›Full record

ArticleCancer biology & therapy2022

Small extracellular vesicle-mediated

Shiv Ram Krishn, Vaughn Garcia, Nicole M Naranjo, Fabio Quaglia, Christopher D Shields, Maisha A Harris, Andrew V Kossenkov, Qin Liu, Eva Corey, Dario C Altieri and 1 more

Abstract read
In one paragraph

Article in Cancer biology & therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Exploring the role of ITGB6: fibrosis, cancer, and other diseases.Apoptosis : an international journal on programmed cell death · 2024
    Review
  5. Article
  6. Article
  7. Targeting the αVβ3/NgR2 pathway in neuroendocrine prostate cancer.Matrix biology : journal of the International Society for Matrix Biology · 2023
    Article
  8. Journal of fungi (Basel, Switzerland) · 2023
    Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shiv Ram KrishnProstate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA USA.
Vaughn GarciaProstate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA USA.
Nicole M NaranjoProstate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA USA.
Fabio QuagliaProstate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA USA.
Christopher D ShieldsProstate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA USA.
Maisha A HarrisProstate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA USA.
Andrew V KossenkovCenter for Systems and Computational Biology, the Wistar Institute, Philadelphia, PA USA.
Qin LiuMolecular and Cellular Oncogenesis Program, the Wistar Institute, Philadelphia, PA USA.ORCID 0000-0001-9964-580X
Eva CoreyDepartment of Urology, University of Washington, Seattle, WA USA.
Dario C AltieriProstate Cancer Discovery and Development Program, the Wistar Institute, Philadelphia, PA USA.
Lucia R LanguinoProstate Cancer Discovery and Development Program, Thomas Jefferson University, Philadelphia, PA USA.

Funding

X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI Andrew Chapman · 1995 to 2026
$94.8M
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
TRANSCRIPTOME AND PROTEOME STRATIFICATION OF PROSTATE ADENOCARCINOMA PHENOTYPESP50CA097186 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETER S NELSON · 2002 to 2026
$58.1M
Steroid Metabolism in Castration-Resistant Prostate CancerP01CA163227 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PETER S NELSON · 2013 to 2026
$25.0M
Role of Runx2 in prostate tumorigenesis and metastasisP01CA140043 · NCI · WISTAR INSTITUTE · PI ALTIERI, DARIO C · 2010 to 2021
$12.2M
Tumor PlasticityR35CA220446 · NCI · WISTAR INSTITUTE · PI ALTIERI, DARIO C · 2017 to 2023
$7.7M
Integrin-mediated mechanisms of prostate cancer progressionR01CA224769 · NCI · THOMAS JEFFERSON UNIVERSITY · PI LANGUINO, LUCIA R. · 2018 to 2022
$2.0M
Integrative Approach to Comprehensive Analysis of High Throughput Data on a Cancer Center LevelR50CA211199 · NCI · WISTAR INSTITUTE · PI Andrew V Kossenkov · 2016 to 2026
$1.6M
NCI NIH HHS P01 CA140043NCI NIH HHS P01 CA163227NCI NIH HHS P30 CA010815NCI NIH HHS P30 CA056036NCI NIH HHS P50 CA097186NCI NIH HHS R01 CA224769NCI NIH HHS R35 CA220446NCI NIH HHS R50 CA211199
6 · The paper itself

Abstract

The αVβ6 integrin, an epithelial-specific cell surface receptor absent in normal prostate and expressed during prostate cancer (PrCa) progression, is a therapeutic target in many cancers. Here, we report that transcript levels of

Indexed as

Extracellular VesiclesProstatic NeoplasmsAnimalsAntigens, NeoplasmDisease Models, AnimalHumansIntegrin beta ChainsIntegrinsMaleProstateReceptors, AndrogenRNA, Small InterferingAntigens, Neoplasmintegrin alphavbeta6integrin beta6Integrin beta ChainsIntegrinsReceptors, AndrogenRNA, Small InterferingAdhesionandrogen receptorelectroporationintegrinmigrationprostate cancersiRNAsmall extracellular vesiclestherapy

Identifiers

PMID35188070
PMCPMC8865252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.