Evidence map›Paper›PMID 35188062›Full record

ArticleRNA biology2022

Flexible pri-miRNA structures enable tunable production of 5' isomiRs.

Xavier Bofill-De Ros, Zhenyi Hong, Ben Birkenfeld, Sarangelica Alamo-Ortiz, Acong Yang, Lisheng Dai, Shuo Gu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Therapeutic AASS inhibition by AAV-miRNA rescues glutaric aciduria type I severe phenotype in mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Dynamic Protein-RNA recognition in primary MicroRNA processing.Current opinion in structural biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xavier Bofill-De RosRNA Mediated Gene Regulation Section, RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.ORCID 0000-0002-1630-0652
Zhenyi HongNeural Development Section, Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Ben BirkenfeldRNA Mediated Gene Regulation Section, RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Sarangelica Alamo-OrtizRNA Mediated Gene Regulation Section, RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Acong YangRNA Mediated Gene Regulation Section, RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Lisheng DaiRNA Mediated Gene Regulation Section, RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Shuo GuRNA Mediated Gene Regulation Section, RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.ORCID 0000-0002-7924-5363

Funding

Uncover the mechanisms regulating the biogenesis and decay of miRNAs in cancerZIABC011566 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GU, SHUO · 2014 to 2025
$16.3M
Intramural NIH HHS ZIA BC011566
6 · The paper itself

Abstract

The Drosha cleavage of a pri-miRNA defines mature microRNA sequence. Drosha cleavage at alternative positions generates 5' isoforms (isomiRs) which have distinctive functions. To understand how pri-miRNA structures influence Drosha cleavage, we performed a systematic analysis of the maturation of endogenous pri-miRNAs and their variants both

Indexed as

Nucleic Acid ConformationHumansMicroRNAsRibonuclease IIIRNA CleavageRNA IsoformsStructure-Activity RelationshipMicroRNAsRibonuclease IIIRNA Isoforms5’ isomiRsalternative cleavagecleavage fidelitydicerDroshapri-miRNARNA-binding proteinsRNA structure

Identifiers

PMID35188062
PMCPMC8865264

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.