Evidence map›Paper›PMID 35188051›Full record

ArticlePharmaceutical biology2022

Narendra Babu Kondapalli, Rajkumar Hemalatha, Satyanarayana Uppala, Srinivas Reddy Yathapu, Shujauddin Mohammed, Mullapudi Venkata Surekha, Ananthan Rajendran, Dinesh Kumar Bharadwaj

Registry-linked trialAbstract read
In one paragraph

Article in Pharmaceutical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06787222 (Effectiveness and Safety of Zingiber Officinale Transdermal Patch for Acne Vulgaris; Study of Interleukin 1 and Skin Microbiome), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06787222 phase2 / phase3active not recruitingnot on this mapstarted 2024, after this paper: background citation

Effectiveness and Safety of Zingiber Officinale Transdermal Patch for Acne Vulgaris; Study of Interleukin 1 and Skin Microbiome

TypeinterventionalSponsorHasanuddin UniversityRan2024 to 2025Enrolled26ConditionsAcne VulgarisArmstretinoin 0.025% + Z. officinale patch, tretinoin 0.025% cream
3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Narendra Babu KondapalliDepartment of Microbiology & Immunology, ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India.
Rajkumar HemalathaDepartment of Microbiology & Immunology, ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India.
Satyanarayana UppalaDr. Pinnamaneni, Siddhartha Institute of Medical Sciences, Vijayawada, Andhra Pradesh, India.
Srinivas Reddy YathapuDepartment of Microbiology & Immunology, ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India.
Shujauddin MohammedDepartment of Microbiology & Immunology, ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India.
Mullapudi Venkata SurekhaDepartment of Pathology, ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India.ORCID 0000-0003-0088-8444
Ananthan RajendranFood Chemistry Division, ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India.
Dinesh Kumar BharadwajFood and Drug Toxicology department, ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

context

objectiveActive phytoconstituents of OS, ZO, PN hydro-alcoholic extracts and their effects on gut microbiota, basal inflammation and lipid profile were investigated in rats. MATERIALS AND

methodsActive phytoconstituents of extracts were analysed using HPLC and GC-MS. SD rats were supplemented with individual/combined extracts (OS-850; ZO-500; PN-100 mg/kg Bw) and Fructooligosaccharide (standard prebiotic-5g/kg-Bw), orally for 30 days. Haematology, lipid profile, LPS, CRP, IL-6, insulin and histology of vital organs were analysed. Caecal bacterial levels were assessed by RT-PCR.

resultsHigh content of phenolic compounds luteolin-7- DISCUSSION AND

conclusionsThe current study could be first of its kind in exploring prebiotic potential of OS, ZO, PN and their effect on native gut bacterial population.

Indexed as

AnimalsAnti-Inflammatory AgentsFemaleGastrointestinal MicrobiomeInflammationLipidsMedicine, TraditionalOcimum sanctumOils, VolatilePiper nigrumPlant ExtractsPrebioticsRatsRats, Sprague-DawleyZingiber officinaleAnti-Inflammatory AgentsLipidsOils, VolatilePlant ExtractsPrebioticsbeneficial bacteriaessential oilsHerbal extracts on endotoxinphenolic compoundssystemic inflammation

Identifiers

PMID35188051
PMCPMC8865113

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.