ArticleLeukemia & lymphoma2022
Serum ferritin levels in previously untreated classical Hodgkin lymphoma: correlations and prognostic significance.
Article in Leukemia & lymphoma, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Clinical and Laboratory Discriminators for Tuberculosis and Lymphoma in Adults Presenting with Fever of Unknown Origin: A Prospective Cohort Study.International journal of general medicine · 2026Article
- Modified Endothelial Activation and Stress Index: A New Predictor for Survival Outcomes in Classical Hodgkin Lymphoma Treated with Doxorubicin-Bleomycin-Vinblastine-Dacarbazine-Based Therapy.Diagnostics (Basel, Switzerland) · 2025Article
- Primary Bone Marrow Hodgkin's Lymphoma Debuting As Hemophagocytic Lymphohistiocytosis in a Patient With HIV.Cureus · 2024Article
- Prognostic Impact of Serum βCancers · 2024Article
- A Nomogram-Based Prognostic Model for Lymphoma Patients Initially Presenting with Fever of Unknown Origin.Journal of inflammation research · 2024Article
- Prognostic role of pretreatment serum ferritin concentration in lung cancer patients: A meta-analysis.World journal of clinical cases · 2022Article
- Serum Procalcitonin Levels in Newly Diagnosed Hodgkin Lymphoma: Correlation with Other Inflammatory Biomarkers.Medicina (Kaunas, Lithuania) · 2022Article
- Primary Bone Marrow HIV-Associated Hodgkin Lymphoma Complicated by Hemophagocytic Lymphohistiocytosis.Genes · 2022Article
- Ferritin, sex, and the wildfire of inflammation in Hodgkin lymphoma.Leukemia & lymphoma · 2022Article
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Abstract
Serum ferritin (SF) is frequently elevated in classical Hodgkin lymphoma (cHL). We report on its prognostic significance in an unselected series of 529 cHL patients treated with state-of-the-art therapy. Higher baseline levels correlated with markers of advanced/aggressive disease. SF levels were significantly higher in male and older patients, those with high body mass index and mixed cellularity histology. The strongest correlation was recorded between SF and complement reactive protein (CRP) levels. Gender-specific SF cutoffs which provided the best discrimination in terms of freedom from progression (FFP) were identified. In multivariate analysis elevated SF levels, advanced stage and high lactate dehydrogenase (LDH) were independent prognostic factors of inferior FFP. SF also appears to retain independent prognostic significance for progression-free survival (PFS) but not for overall survival (OS). In conclusion, SF levels in cHL reflect disease activity and are associated with adverse patient outcomes.
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