ArticleAmerican journal of physiology. Endocrinology and metabolism2022
Role of the arterial baroreflex in the sympathetic response to hyperinsulinemia in adult humans.
Article in American journal of physiology. Endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Physiological influences on neurovascular coupling: A systematic review of multimodal imaging approaches and recommendations for future study designs.Experimental physiology · 2025Pooled it
- Beneficial vascular effects of oral phosphatidylserine supplementation in type 2 diabetes.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Trial
- The insulin resistance-systemic vascular resistance-isolated diastolic hypertension axis: a metabolic framework for an overlooked hypertension phenotype.Frontiers in cardiovascular medicine · 2026Review
- Trends in the prevalence of apparent treatment-resistant hypertension among U.S. adults, 1999-2018.American journal of preventive cardiology · 2025Article
- Postprandial Hypotension in Adults: Exploring Insulin Dynamics During a Mixed Meal Test.Nutrients · 2025Article
- Effect of insulin on indices of cerebral blood flow and cerebrovascular compliance in young adults.American journal of physiology. Heart and circulatory physiology · 2025Article
- Association of the Triglyceride-Glucose Index With Resistant Hypertension and a Nomogram Model Construction.Journal of the American Heart Association · 2024Article
- Interaction of simultaneous hypoxia and baroreflex loading on control of sympathetic action potential subpopulations.Journal of neurophysiology · 2024Article
- Effect of acute intranasal insulin administration on muscle sympathetic nerve activity in healthy young adults.American journal of physiology. Heart and circulatory physiology · 2024Article
- Altered Autonomic Function in Metabolic Syndrome: Interactive Effects of Multiple Components.Journal of clinical medicine · 2024Review
- Differences in Heart Rate Variability and Baroreflex Sensitivity between Male and Female Athletes.Journal of clinical medicine · 2023Article
- Sympathetic transduction to blood pressure during euglycemic-hyperinsulinemia in young healthy adults: role of burst amplitude.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Impact of sex and diet-induced weight loss on vascular insulin sensitivity in type 2 diabetes.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Role of the Autonomic Nervous System in the Hemodynamic Response to Hyperinsulinemia-Implications for Obesity and Insulin Resistance.Current diabetes reports · 2022Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Muscle sympathetic nerve activity (MSNA) increases during hyperinsulinemia, primarily attributed to central nervous system effects. Whether peripheral vasodilation induced by insulin further contributes to increased MSNA via arterial baroreflex-mediated mechanisms requires further investigation. Accordingly, we examined baroreflex modulation of the MSNA response to hyperinsulinemia. We hypothesized that rescuing peripheral resistance with coinfusion of the vasoconstrictor phenylephrine would attenuate the MSNA response to hyperinsulinemia. We further hypothesized that the insulin-mediated increase in MSNA would be recapitulated with another vasodilator (sodium nitroprusside, SNP). In 33 young healthy adults (28 M/5F), MSNA (microneurography) and arterial blood pressure (BP, Finometer/brachial catheter) were measured, and total peripheral resistance (TPR, ModelFlow) and baroreflex sensitivity were calculated at rest and during intravenous infusion of insulin (
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Registered trials
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