Evidence map›Paper›PMID 35187880›Full record

ArticleJournal of veterinary science2022

Treatment of pigs with enrofloxacin via different oral dosage forms - environmental contaminations and resistance development of

Paula Janssen, Gesine Barton, Manfred Kietzmann, Jessica Meißner

Open access · goldAbstract read
In one paragraph

Article in Journal of veterinary science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Resistance Mechanisms of Fluoroquinolone inAntibiotics (Basel, Switzerland) · 2025
    Article
  3. Article
  4. MinisculeSustainable microbiology · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Paula JanssenFraunhofer ITEM, Hannover 30625, Germany.ORCID https://orcid.org/0000-0001-6243-470X
Gesine BartonBASF SE, Ludwigshafen am Rhein 67056, Germany.ORCID https://orcid.org/0000-0001-7941-6057
Manfred KietzmannDepartment of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Foundation, Hannover 30559, Germany.ORCID https://orcid.org/0000-0001-5426-0631
Jessica MeißnerDepartment of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Foundation, Hannover 30559, Germany. Jessica.meissner@tiho-hannover.de.ORCID https://orcid.org/0000-0002-7263-848X
University of Veterinary Medicine Hannover, Foundation · DEBASF (Germany) · DEFraunhofer Institute for Toxicology and Experimental Medicine · DE

Funding

Deutsche ForschungsgemeinschaftESBL and (fluoro)quinolone Resistance in Enterobacteriaceae 01KI1013AStiftung Tierärztliche Hochschule Hannover
6 · The paper itself

Abstract

backgroundAntibacterial agents play important roles in the treatment of bacterial infections. However, the development of antimicrobial resistance (AMR) and carry-over of substances into the environment are several problems arising during oral treatment of bacterial infections. We assessed AMR development in commensal

methodsIn each trial, six pigs were treated with enrofloxacin via powder, granulate or pellet forms in two time periods (days 1-5 and 22-26). Four pigs served as untreated controls. The minimum inhibitory concentration (MIC) was determined to evaluate AMR development. Analysis of enro- and ciprofloxacin was performed with high performance liquid chromatography.

resultsNon-wildtype

conclusionsThis study indicates that the kind of the oral dosage form of antibiotics affects environmental contamination and AMR development in commensal

Indexed as

Escherichia coliEscherichia coli InfectionsAnimalsAnti-Bacterial AgentsDrug Resistance, BacterialEnrofloxacinFluoroquinolonesMicrobial Sensitivity TestsSwineAnti-Bacterial AgentsEnrofloxacinFluoroquinolonesaerosolantibiotic resistanceDustenvironmental pollutionswine

Identifiers

PMID35187880
PMCPMC8977541
OpenAlexW4207040630

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.