ArticleAngewandte Chemie (International ed. in English)2022
Phase Separation of Oppositely Charged Polymers Regulates Bioinspired Silicification.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Macromolecular Condensates as Tunable Scaffolds for Bio-Inspired Silica Hybrids.Angewandte Chemie (International ed. in English) · 2026Article
- The Role of Confinement in Biomineralization.Chemical reviews · 2025Review
- Cytomimetic calcification in chemically self-regulated prototissues.Nature communications · 2025Article
- The structure of His15 acetamide-modified hen egg-white lysozyme: a nice surprise from an old friend.Acta crystallographica. Section F, Structural biology communications · 2025Article
- Bio-Informed Porous Mineral-Based Composites.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- A pH-Dependent Phase Separation Drives Polyamine-Mediated Silicification from Undersaturated Solutions.ACS nano · 2024Article
- Hexagonal Patterns in Diatom Silica Form via a Directional Two-Step Process.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- An Atomistic View on the Mechanism of Diatom Peptide-Guided Biomimetic Silica Formation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Silica deposition in plants: scaffolding the mineralization.Annals of botany · 2023Review
- Polymer-Rich Dense Phase Can Concentrate Metastable Silica Precursors and Regulate Their Mineralization.ACS biomaterials science & engineering · 2023Article
- Article
- Lysozyme is Sterically Trapped Within the Silica Cage in Bioinspired Silica-Lysozyme Composites: A Multi-Technique Understanding of Elusive Protein-Material Interactions.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Phase Separation of Oppositely Charged Polymers Regulates Bioinspired Silicification.Angewandte Chemie (International ed. in English) · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In nature, simple organisms evolved mechanisms to form intricate biosilica nanostructures, far exceeding current synthetic manufacturing. Based on the properties of extracted biomacromolecules, polycation-polyanion pairs were suggested as moderators of biosilica formation. However, the chemical principles of this polymer-induced silicification remain unclear. Here, we used a biomimetic polycation-polyanion system to study polymer-induced silicification. We demonstrate that it is the polymer phase separation process, rather than silica-polymer interactions, which controls silica precipitation. Since ionic strength controls this electrostatic phase separation, it can be used to tune the morphology and structure of the precipitates. In situ cryo electron microscopy highlights the pivotal role of the hydrated polymer condensates in this process. These results pave the road for developing nanoscale morphologies of bioinspired silica based on the chemistry of liquid-liquid phase separation.
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Registered trials
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