Evidence map›Paper›PMID 35187756›Full record

ArticleHead & neck2022

Tumor molecular differences associated with outcome disparities of Black patients with head and neck cancer.

Hugh A J Kim, Peter Y F Zeng, Alana Sorgini, Mushfiq H Shaikh, Halema Khan, Danielle MacNeil, Mohammed I Khan, Adrian Mendez, John Yoo, Kevin Fung and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. The prognosis and treatment of newly diagnosed bone metastasis of head and neck squamous cell cancer: an analysis of racial disparity.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Hugh A J KimDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.ORCID 0000-0002-8424-148X
Peter Y F ZengDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
Alana SorginiDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.ORCID 0000-0002-4796-5286
Mushfiq H ShaikhDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
Halema KhanDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
Danielle MacNeilDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.ORCID 0000-0001-6666-9055
Mohammed I KhanDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
Adrian MendezDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
John YooDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
Kevin FungDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
Pencilla LangDepartment of Microbiology & Immunology, University of Western Ontario, London, Ontario, Canada.
David A PalmaDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
Joe S MymrykDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
John W BarrettDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
Krupal B PatelDepartment of Otolaryngology, Moffitt Cancer Center, Tampa, Florida, USA.ORCID 0000-0002-2285-0386
Paul C BoutrosDepartment of Human Genetics, University of California, Los Angeles, California, USA.
Anthony C NicholsDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.ORCID 0000-0002-0760-980X
Western University · CAMoffitt Cancer Center · USUniversity of California, Los Angeles · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Damoiseaux · 1985 to 2026
$134.5M
Advancing method benchmarking and data sharing through crowd-sourced competitions in cancer researchU24CA248265 · NCI · SAGE BIONETWORKS · PI BOUTROS, PAUL CHRISTOPHER, VARMA, SUSHEEL · 2020 to 2024
$4.1M
NCI NIH HHS P30 CA016042NCI NIH HHS U24 CA248265
6 · The paper itself

Abstract

backgroundNumerous studies of head and neck squamous cell carcinoma (HNSCC) have demonstrated disparate outcomes by race and ethnicity. Beyond known associations with socioeconomic variables, whether these are also associated with differences in tumor molecular composition has thus far been poorly explored.

methodsWe downloaded clinical and multiplatform molecular data from The Cancer Genome Atlas and other published studies. These were compared between non-Hispanic Black (n = 43) and White (n = 354) patients with non-HPV-related tumors, using multivariable models. Publicly available validation cohorts were used.

resultsBlack patients had poorer progression-free survival than White patients. Tumors of Black patients had greater copy number aberrations, and increased SFRP1 methylation and miRNA-mediated PRG4 silencing associated with poor survival. PI3K/AkT/mTOR pathway proteins were differentially expressed.

conclusionsThere are molecular differences between tumors of Black and White patients that may partially account for differences in survival. These may inform targeted treatment decisions to achieve equitable outcomes.

Indexed as

Black PeopleHead and Neck NeoplasmsHealth Status DisparitiesSquamous Cell Carcinoma of Head and NeckHumansSurvival RateWhite PeoplegenomicsHNSCCHPV-negativemutational statusracio-ethnic group

Identifiers

PMID35187756
PMCPMC9047510
OpenAlexW4212827976

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.