Evidence map›Paper›PMID 35187580›Full record

ArticleMedical microbiology and immunology2022

Impaired detection of omicron by SARS-CoV-2 rapid antigen tests.

Andreas Osterman, Irina Badell, Elif Basara, Marcel Stern, Fabian Kriesel, Marwa Eletreby, Gamze Naz Öztan, Melanie Huber, Hanna Autenrieth, Ricarda Knabe and 11 more

Open access · hybridAbstract read
In one paragraph

Article in Medical microbiology and immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 2 pooled it
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 124 citations in OpenAlex.

  1. The Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19: Antigen Testing (January 2023).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Guideline
  2. Pooled it
  3. A multi-country phase 2 study to evaluate the suitcase lab for rapid detection of SARS-CoV-2 in seven Sub-Saharan African countries: Lessons from the field.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2023
    Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 2 countries.

Andreas OstermanMax Von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU München, Feodor-Lynen-Str. 23, 81377, Munich, Germany.ORCID http://orcid.org/0000-0001-5435-5972
Irina BadellMax Von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU München, Feodor-Lynen-Str. 23, 81377, Munich, Germany.
Elif BasaraMax Von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU München, Feodor-Lynen-Str. 23, 81377, Munich, Germany.
Marcel SternMax Von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU München, Feodor-Lynen-Str. 23, 81377, Munich, Germany.ORCID http://orcid.org/0000-0002-7692-6905
Fabian KrieselMax Von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU München, Feodor-Lynen-Str. 23, 81377, Munich, Germany.
Marwa EletrebyMax Von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU München, Feodor-Lynen-Str. 23, 81377, Munich, Germany.
Gamze Naz ÖztanMax Von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU München, Feodor-Lynen-Str. 23, 81377, Munich, Germany.
Melanie HuberMax Von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU München, Feodor-Lynen-Str. 23, 81377, Munich, Germany.
Hanna AutenriethMax Von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU München, Feodor-Lynen-Str. 23, 81377, Munich, Germany.
Ricarda KnabeMax Von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU München, Feodor-Lynen-Str. 23, 81377, Munich, Germany.
Patricia M SpäthMax Von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU München, Feodor-Lynen-Str. 23, 81377, Munich, Germany.
Maximilian MuenchhoffMax Von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU München, Feodor-Lynen-Str. 23, 81377, Munich, Germany.ORCID http://orcid.org/0000-0001-7016-0470
Alexander GrafLaboratory for Functional Genome Analysis, Gene Center, LMU München, Munich, Germany.ORCID http://orcid.org/0000-0003-4435-6861
Stefan KrebsLaboratory for Functional Genome Analysis, Gene Center, LMU München, Munich, Germany.ORCID http://orcid.org/0000-0001-5112-9507
Helmut BlumLaboratory for Functional Genome Analysis, Gene Center, LMU München, Munich, Germany.ORCID http://orcid.org/0000-0002-3994-2332
Jürgen DurnerLabor Becker MVZ GbR, Munich, Germany.
Ludwig CzibereLabor Becker MVZ GbR, Munich, Germany.ORCID http://orcid.org/0000-0002-7508-5841
Christopher DächertMax Von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU München, Feodor-Lynen-Str. 23, 81377, Munich, Germany.ORCID http://orcid.org/0000-0001-6441-3099
Lars KaderaliInstitute of Bioinformatics, University Medicine Greifswald, Felix-Hausdorff-Str. 8, 17475, Greifswald, Germany. lars.kaderali@uni-greifswald.de.ORCID http://orcid.org/0000-0002-2359-2294
Hanna-Mari BaldaufMax Von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU München, Feodor-Lynen-Str. 23, 81377, Munich, Germany. baldauf@mvp.lmu.de.ORCID http://orcid.org/0000-0003-0589-697X
Oliver T KepplerMax Von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU München, Feodor-Lynen-Str. 23, 81377, Munich, Germany. keppler@mvp.lmu.de.ORCID http://orcid.org/0000-0002-1384-8946
Ludwig-Maximilians-Universität München · DELMU Klinikum · DEDepartment of Virology · FRGerman Center for Infection Research · DEGoethe Institut · DEUniversitätsmedizin Greifswald · DE

Funding

Free State of Bavaria BayVOCFree State of Bavaria FOR-COVID
6 · The paper itself

Abstract

Since autumn 2020, rapid antigen tests (RATs) have been implemented in several countries as an important pillar of the national testing strategy to rapidly screen for infections on site during the SARS-CoV-2 pandemic. The current surge in infection rates around the globe is driven by the variant of concern (VoC) omicron (B.1.1.529). Here, we evaluated the performance of nine SARS-CoV-2 RATs in a single-centre laboratory study. We examined a total of 115 SARS-CoV-2 PCR-negative and 166 SARS-CoV-2 PCR-positive respiratory swab samples (101 omicron, 65 delta (B.1.617.2)) collected from October 2021 until January 2022 as well as cell culture-expanded clinical isolates of both VoCs. In an assessment of the analytical sensitivity in clinical specimen, the 50% limit of detection (LoD50) ranged from 1.77 × 10

Indexed as

COVID-19SARS-CoV-2HumansPandemicsDiagnostic testLateral flowNucleocapsid proteinSARS-CoV-2 rapid antigen testSensitivitySpecificityVoC

Identifiers

PMID35187580
PMCPMC8858605
OpenAlexW4213199075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.