Evidence map›Paper›PMID 35187526›Full record

ArticleFrontiers in digital health2021

The Role of Carbon Dioxide in the Rat Acute Stroke Penumbra.

Leonard L Yeo, Fabian Arnberg, Arvin Chireh, Vijay Sharma, Benjamin Tan, Vamsi Gontu, Philip Little, Staffan Holmin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in digital health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Leonard L YeoDepartments of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.
Fabian ArnbergDepartments of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.
Arvin ChirehDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Vijay SharmaDivision of Neurology, Department of Medicine, National University Health System, Singapore, Singapore.
Benjamin TanDivision of Neurology, Department of Medicine, National University Health System, Singapore, Singapore.
Vamsi GontuDepartments of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.
Philip LittleDepartments of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.
Staffan HolminDepartments of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.
Karolinska Institutet · SENational University of Singapore · SGKarolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe vasodilatory response to inhaled CO

methodsTwenty-two Sprague-Dawley rats were subjected to 90-min occlusion of the M2 segment of the middle cerebral artery (M2CAO) by endovascular technique. The animals were administered different C02 concentrations and scanned serially with 9.4 T MRI. Infarct tissue was determined by diffusion-weighted imaging (DWI) and hypoperfused tissue was determined by arterial spin labeling (PWI).

results4 animals were administered room air (RA)+ 6% CO

conclusionInhaled CO

Indexed as

acute strokearterial spin label (ASL) MRIcarbon dioxidemiddle cerebral arterial occlusionpenumbraRat—brain

Identifiers

PMID35187526
PMCPMC8854855
OpenAlexW4210624437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.