Evidence map›Paper›PMID 35187520›Full record

ArticleBBA advances2022

The dynamic nature of the coronavirus receptor, angiotensin-converting enzyme 2 (ACE2) in differentiating airway epithelia.

Vincent J Manna, Hana Choi, Shawna M Rotoli, Salvatore J Caradonna

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BBA advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Mechanistic studies of MALAT1 in respiratory diseases.Frontiers in molecular biosciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Vincent J MannaDepartment of Molecular Biology, Graduate School of Biomedical Sciences and School of Osteopathic Medicine, Rowan University, Stratford, NJ, United States.
Hana ChoiDepartment of Molecular Biology, Graduate School of Biomedical Sciences and School of Osteopathic Medicine, Rowan University, Stratford, NJ, United States.
Shawna M RotoliDepartment of Molecular Biology, Graduate School of Biomedical Sciences and School of Osteopathic Medicine, Rowan University, Stratford, NJ, United States.
Salvatore J CaradonnaDepartment of Molecular Biology, Graduate School of Biomedical Sciences and School of Osteopathic Medicine, Rowan University, Stratford, NJ, United States.
Rowan University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Once inhaled, SARS-CoV-2 particles enter respiratory ciliated cells by interacting with angiotensin converting enzyme 2 (ACE2). Understanding the nature of ACE2 within airway tissue has become a recent focus particularly in light of the COVID-19 pandemic. Airway mucociliary tissue was generated

Indexed as

AbbreviationsACE2, angiotensin converting enzyme 2ALI, air-liquid interfaceAng, angiotensinCOVID-19, coronavirus disease 2019HNEC, human nasal endothelial cellshs, homo sapienIP, immunoprecipitationPNGase F, Peptide:N glycosidase FRAS, renin-angiotensin systemRmAb, rabbit monoclonal antibodyRpAb, rabbit polyclonal antibodysACE2, soluble/released form of ACE2SARS-CoV-2, severe acute respiratory syndrome coronavirus 2SDS-PAGE, sodium dodecyl sulfate – polyacrylamide gel electrophoresisTCE, total cell extractUTR, untranslated region

Identifiers

PMID35187520
PMCPMC8840828
OpenAlexW4212996497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.