ArticleNature aging2021
Evidence for accelerated aging in mammary epithelia of women carrying germline
Open access · hybridAbstract read
In one paragraph
Article in Nature aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
10.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 85 citations in OpenAlex.
- The genetic relationship between ADHD and shortened telomeres points to neurodevelopmental mechanisms.Translational psychiatry · 2026Article
- Discovery and Evaluation of Biomarkers for Triple-Negative Breast Cancer Subtypes Uncovers Patient Stratification and Targeted Therapeutic Strategies.Cancer research · 2026Article
- MechanoAge, a machine learning platform to identify individuals susceptible to breast cancer based on mechanical properties of single cells.EBioMedicine · 2026Article
- Can DNA Methylation in Peritumoral and Contralateral Breast Tissue Predict Recurrence or Second Breast Cancers?Current issues in molecular biology · 2026Article
- YAP1 Dysfunction Promotes Molecular Properties Linked to Breast Cancer Susceptibility.Cancer prevention research (Philadelphia, Pa.) · 2026Article
- Single-cell spatial atlas of the aging human breast.Nature aging · 2026Article
- Branching out: the diverse roles of stem and progenitor cells in mammary gland development.Journal of mammary gland biology and neoplasia · 2026Review
- Divergent aging of nulliparous and parous mammary glands reveals IL33+ hybrid epithelial cells.Nature communications · 2026Article
- Signaling pathways and targeted interventions for precancers.Signal transduction and targeted therapy · 2026Review
- The breakome of BRCA1 and BRCA2 pathway mutation carriers reveals early processes in breast oncogenesis.Cell death & disease · 2025Article
- Implantation of engineered adipocytes suppresses tumor progression in cancer models.Nature biotechnology · 2025Article
- Cancer and Aging Biomarkers: Classification, Early Detection Technologies and Emerging Research Trends.Biosensors · 2025Review
- Ageing, immune fitness and cancer.Nature reviews. Cancer · 2025Review
- Tissue specificity of ageing in cancer risk prediction.Nature reviews. Cancer · 2025Article
- CD105Breast cancer research : BCR · 2025Article
- Epigenomic disorder and partial EMT impair luminal progenitor integrity in Brca1-associated breast tumorigenesis.Molecular cancer · 2025Article
- Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube.Nature communications · 2025Article
- Thirty Years of BRCA1: Mechanistic Insights and Their Impact on Mutation Carriers.Cancer discovery · 2025Review
- ERα dysfunction caused by ESR1 mutations and therapeutic pressure promotes lineage plasticity in ERNature cancer · 2025Article
- Cells-of-Origin of Breast Cancer and Intertumoral Heterogeneity.Advances in experimental medicine and biology · 2025Review
Corrections and comments
- Commented on by
Authors and funding
12 authors at 4 institutions in 3 countries.
Sundus F ShalabiDepartment of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0002-8440-2474
Masaru MiyanoDepartment of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Rosalyn W SayamanDepartment of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Jennifer C LopezDepartment of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Tiina A JokelaDepartment of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Michael E TodhunterDepartment of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Stefan HinzDepartment of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA, USA.
James C GarbeBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-4041-3868
Martha R StampferBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Kai KessenbrockBiological Chemistry Department, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0003-0410-6104
Victoria E SeewaldtDepartment of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA, USA. vseewaldt@coh.org.ORCID http://orcid.org/0000-0002-7289-9268
Mark A LaBargeDepartment of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA, USA. mlabarge@coh.org.ORCID http://orcid.org/0000-0003-2405-4719
City of Hope · USLawrence Berkeley National Laboratory · USAl-Quds University · PSUniversity of California, Irvine · US
Funding
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3MProject 2U54CA285116 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Victoria L. Seewaldt · 2023 to 2026
$6.8MGeriatric Oncology Research Infrastructure to Improve Clinical CareR33AG059206 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI WILLIAM DALE, Heidi Diana Klepin · 2020 to 2026
$5.1MMechanical Phenotyping of Random Periaerolar Fine Needle Aspiration-Collected Cells for Early Breast Cancer DetectionR01EB024989 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI Mark A LaBarge, Lydia L Sohn · 2017 to 2026
$4.8MMicroenvironmental regulation of breast tumorigenesisR01CA234496 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kai Kessenbrock · 2019 to 2026
$4.3MDiversity Supplement to Combined Breast MRI/Biomarker Strategies to Identify Aggressive BiologyU01CA189283 · NCI · DUKE UNIVERSITY · PI CLINTON, STEVEN K, MIRANDA-CARBONI, GUSTAVO ADOLFO · 2015 to 2020
$4.0MUnderstanding breast cancer progression as a defect in the mechanics of tissue self-organizationU01CA244109 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GARTNER, ZEV JORDAN, GOGA, ANDREI · 2020 to 2024
$3.0MTension-Stat3-miR-mediated metastasisR01CA192914 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEEWALDT, VICTORIA L., WEAVER, VALERIE MARIE · 2015 to 2019
$2.9MInvolution-based biomarkers of breast cancer riskR01CA237602 · NCI · MAYO CLINIC JACKSONVILLE · PI DEGNIM, AMY C, RADISKY, DEREK C · 2020 to 2024
$2.8MMechanisms of breast cancer associated with obesityR01CA170851 · NCI · TUFTS UNIVERSITY BOSTON · PI KUPERWASSER, CHARLOTTE, SEEWALDT, VICTORIA L. · 2012 to 2015
$2.6MCancer Metabolism Training ProgramT32CA221709 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI David K. Ann, Victoria L. Seewaldt · 2018 to 2026
$1.8M2/2 Drug Development and Capacity Building: A UCR/CoH-CCC Partnership (Pilot Project 2)P20CA242620 · NCI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI MARTINEZ, ERNEST · 2019 to 2022
$1.2MNCI NIH HHS P20 CA242619NCI NIH HHS P20 CA242620NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA170851NCI NIH HHS R01 CA192914NCI NIH HHS R01 CA234496NCI NIH HHS R01 CA237602NCI NIH HHS T32 CA221709NCI NIH HHS U01 CA189283NCI NIH HHS U01 CA244109NCI NIH HHS U54 CA285116NIA NIH HHS R33 AG059206NIBIB NIH HHS R01 EB024989
Abstract
During aging in the human mammary gland, luminal epithelial cells lose lineage fidelity by expressing markers normally expressed in myoepithelial cells. We hypothesize that loss of lineage fidelity is a general manifestation of epithelia that are susceptible to cancer initiation. In the present study, we show that histologically normal breast tissue from younger women who are susceptible to breast cancer, as a result of harboring a germline mutation in
Indexed as
Breast NeoplasmsMammary Glands, HumanAgingBRCA1 ProteinBRCA2 ProteinBreastFemaleGerm-Line MutationHumansBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.