Evidence map›Paper›PMID 35187420›Full record

ArticleACS pharmacology & translational science2022

Epidrugs in Amyotrophic Lateral Sclerosis/Frontotemporal Dementia: Contextualizing a Role for Histone Kinase Inhibition in Neurodegenerative Disease.

Samantha N Cobos, Mariana P Torrente

Open access · greenAbstract read
In one paragraph

Article in ACS pharmacology & translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Virtual Special Issue: Epigenetics 2022.ACS pharmacology & translational science · 2022
    Article
  4. Virtual Special Issue: Epigenetics 2022.ACS medicinal chemistry letters · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Samantha N CobosChemistry Department of Brooklyn College, Brooklyn, New York 11210, United States.
Mariana P TorrenteChemistry Department of Brooklyn College, Brooklyn, New York 11210, United States.ORCID https://orcid.org/0000-0001-8220-2228
The Graduate Center, CUNY · US

Funding

Epigenetics In Neurodegenerative Disease: Targeting Histone Modifications in ALSK22NS091314 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TORRENTE, MARIANA PLAZAS · 2015 to 2017
$536k
NINDS NIH HHS K22 NS091314
6 · The paper itself

Abstract

Breakthroughs in understanding the epigenetic mechanisms involved in neurodegenerative disease have highlighted "epidrugs" as a potential avenue for therapeutic development. Here, we expand on the future of epidrugs against neurodegeneration and discuss promising novel targets underexploited thus far: histone kinases.

Identifiers

PMID35187420
PMCPMC8844958
OpenAlexW4206133161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.