Evidence map›Paper›PMID 35187417›Full record

ArticleACS pharmacology & translational science2022

Development of Inhaled GABA

Nicolas M Zahn, M S Rashid Roni, Gene T Yocum, Michelle J Meyer, Daniel A Webb, Md Yeunus Mian, James M Cook, Douglas C Stafford, Charles W Emala, Leggy A Arnold

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Imidazobenzodiazepine PI320 Relaxes Mouse Peripheral Airways by Inhibiting Calcium Mobilization.American journal of respiratory cell and molecular biology · 2022
    Article
  5. Anxiolytics for Bronchodilation: Refinements to GABAAmerican journal of respiratory cell and molecular biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Nicolas M ZahnDepartment of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.
M S Rashid RoniDepartment of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.ORCID https://orcid.org/0000-0002-3105-0540
Gene T YocumDepartment of Anesthesiology, Columbia University, New York, New York 10032, United States.
Michelle J MeyerDepartment of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.
Daniel A WebbDepartment of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.
Md Yeunus MianDepartment of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.ORCID https://orcid.org/0000-0002-7520-1750
James M CookDepartment of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.ORCID https://orcid.org/0000-0001-5512-3022
Douglas C StaffordPantherics Incorporated, La Jolla, California 92037, United States.
Charles W EmalaDepartment of Anesthesiology, Columbia University, New York, New York 10032, United States.
Leggy A ArnoldDepartment of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.ORCID https://orcid.org/0000-0003-1411-1572
University of Wisconsin–Milwaukee · USColumbia University · US

Funding

Anesthetics' Effects on Physiological Responses Modulated by Peripheral GABAA ReceptorsR35GM140880 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EMALA, CHARLES W · 2021 to 2025
$2.0M
Development of new drugs for asthma by targeting GABA(A) receptors in the lungR01HL118561 · NHLBI · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2014 to 2017
$2.0M
GABAA Receptor-Mediated Modulation of Lung InflammationK08HL140102 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI YOCUM, GENE THOMAS · 2018 to 2022
$831k
Development of microencapsulated PI301 targeting lung GABAergic signalingR43HL162474 · NHLBI · PANTHERICS INCORPORATED · PI STAFFORD, DOUGLAS C. · 2022 to 2022
$256k
A novel asthma drug candidate targeting the GABAergic system in lung inflammationR41HL147658 · NHLBI · PANTHERICS INCORPORATED · PI ARNOLD, ALEXANDER · 2019 to 2019
$225k
NHLBI NIH HHS K08 HL140102NHLBI NIH HHS R01 HL118561NHLBI NIH HHS R41 HL147658NHLBI NIH HHS R43 HL162474NIGMS NIH HHS R35 GM140880
6 · The paper itself

Abstract

We report the modification of MIDD0301, an imidazodiazepine GABA

Identifiers

PMID35187417
PMCPMC8844962
OpenAlexW4210299518

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.