Evidence map›Paper›PMID 35187341›Full record

ArticleACS omega2022

Ratiometric Determination of Nitroxyl Utilizing a Novel Fluorescence Resonance Energy Transfer-Based Fluorescent Probe Based on a Coumarin-Rhodol Derivative.

Junhong Xu, Yu Bai, Qiujuan Ma, Jingguo Sun, Meiju Tian, Linke Li, Nannan Zhu, Shuzhen Liu

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Junhong XuDepartment of Dynamical Engineering, North China University of Water Resources and Electric Power, Zhengzhou 450011, PR China.
Yu BaiSchool of Pharmacy and Chemical Engineering, Zhengzhou University of Industrial Technology, Zhengzhou 450011, PR China.
Qiujuan MaSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.ORCID https://orcid.org/0000-0001-9785-2733
Jingguo SunSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.
Meiju TianSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.
Linke LiSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.
Nannan ZhuSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.
Shuzhen LiuSchool of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.
First Affiliated Hospital of Henan University · CNNorth China University of Water Resources and Electric Power · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nitroxyl (HNO) is a member of the reactive nitrogen species, and how to detect it quickly and accurately is a challenging task. In this work, we designed and prepared a fluorescent ratiometric probe based on the fluorescence resonance energy transfer (FRET) mechanism, which can detect HNO with high selectivity. The coumarin derivative was used as an energy donor, the rhodol derivative was applied as an energy receptor, and 2-(diphenylphosphine)benzoate was utilized as the recognition group to detect nitroxyl. In the absence of HNO, the rhodol derivative exists in a non-fluorescent spironolactone state, and the FRET process is inhibited. Upon adding HNO, the closed spironolactone form is transformed into a conjugated xanthene structure and the FRET process occurs. This probe could specifically recognize nitroxyl, showing high sensitivity and selectivity. When the HNO concentration was changed from 3.0 × 10

Identifiers

PMID35187341
PMCPMC8851634
OpenAlexW4210519209

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.