Evidence map›Paper›PMID 35187067›Full record

ArticleFrontiers in molecular biosciences2021

Aspirin Repurposing in Folate-Decorated Nanoparticles: Another Way to Target Breast Cancer.

Fariha Kanwal, Mingming Ma, Muhammad Fayyaz Ur Rehman, Fahim-Ullah Khan, Shai E Elizur, Aima Iram Batool, Chi Chiu Wang, Tahira Tabassum, Changrui Lu, Yao Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Fariha KanwalSchool of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China.
Mingming MaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Key Laboratory of Ocular Fundus Diseases, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.
Muhammad Fayyaz Ur RehmanInstitute of Chemistry, University of Sargodha, Sargodha, Pakistan.
Fahim-Ullah KhanDepartment of Biotechnology, University of Science and Technology, Bannu, Pakistan.
Shai E ElizurIVF Unit, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Aima Iram BatoolDepartment of Zoology, University of Sargodha, Sargodha, Pakistan.
Chi Chiu WangDepartment of Obstetrics and Gynecology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Tahira TabassumDepartment of Pathology, Sargodha Medical College, University of Sargodha, Sargodha, Pakistan.
Changrui LuDepartment of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China.
Yao WangDepartment of Assisted Reproduction, School of Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
University of Sargodha · PKShanghai Jiao Tong University · CNChinese University of Hong Kong · CNDonghua University · CNShanghai First People's Hospital · CNSheba Medical Center · ILUniversity of Science and Technology Bannu · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer affects more than 1 million women per year worldwide. Through this study, we developed a nanoparticle-based drug delivery system to target breast cancer cells. Aspirin has been found to inhibit thromboembolic diseases with its tumor-preventing activity. As a consequence, it relieves disease symptoms and severity. Here, mesoporous silica nanoparticles (MNPs) have been used to deliver aspirin to the tumor location. MNP-based aspirin in folic acid (F)-conjugated polydopamine (MNP-Asp-PD-PG-F) vehicles are prepared for targeted breast cancer therapy. The vehicle hinges on MNP altered with polymer polyethylene glycol (PG), polydopamine (PD), and F. The delivery vehicle was studied for

Indexed as

aspirinbreast cancermesoporous silicananomedicinenanoparticle

Identifiers

PMID35187067
PMCPMC8848101
OpenAlexW4210471403

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.