SynthesisFrontiers in surgery2021
Endoscopic vs. Microscopic Transsphenoidal Surgery for the Treatment of Pituitary Adenoma: A Meta-Analysis.
Synthesis in Frontiers in surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Outcomes of endoscopic and microscopic transsphenoidal pituitary surgery: evidence from a systematic review, meta-analysis, and institutional experience.Neurosurgical review · 2026Pooled it
- Safety and efficacy of endoscopic vs. microscopic approaches in pituitary adenoma surgery: A systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- "Intrasellar tumor-to-tumor metastasis: A single center experience with a systematic review".Pituitary · 2024Pooled it
- Reported baseline variables in transsphenoidal surgery for pituitary adenoma over a 30 year period: a systematic review.Pituitary · 2023Pooled it
- Comparison of endoscopic and endoscope-assisted microscopic transsphenoidal surgery for pituitary adenoma resection: a prospective randomized study.Frontiers in endocrinology · 2025Trial
- Comparative effectiveness of endoscopic and microscopic adenoma removal in acromegaly.Frontiers in endocrinology · 2023Trial
- Article
- Article
- Nationwide trends and outcomes of transsphenoidal pituitary surgery: A 15-year analysis from the public healthcare system.Surgical neurology international · 2026Article
- Endoscopic endonasal resection of giant pituitary adenomas - case series from the referral pituitary center.Pituitary · 2025Article
- Article
- Endocrine Outcome and Quality of Life After Transsphenoidal Resection of Pituitary Adenoma-A Prospective Randomized Single-Blinded Study Comparing Endoscopic Versus Microscopic Resection.Neurology international · 2025Article
- Endoscopic and exoscopic surgery for brain tumors.International journal of clinical oncology · 2024Review
- An unexpected etiology of cerebrospinal fluid leak post-transsphenoidal surgery.Acta neurologica Belgica · 2024Article
- Collaborative Human-Computer Vision Operative Video Analysis Algorithm for Analyzing Surgical Fluency and Surgical Interruptions in Endonasal Endoscopic Pituitary Surgery: Cohort Study.Journal of medical Internet research · 2024Article
- Review
- Insights into Visual Outcomes and Determinants in Pituitary Adenoma Surgery: A 5-Year Retrospective Cohort Study.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Otolaryngology Considerations of Pituitary Surgery: What an Endocrinologist Should Know.Journal of the Endocrine Society · 2023Article
- Endoscopic Endonasal Skull Base Surgery Complication Avoidance: A Contemporary Review.Brain sciences · 2022Review
- Comparison of the endoscopic endonasal to microscopic sublabial transsphenoidal approach in a case series of pituitary macroadenomas.Medicine internationalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCurrently, endoscopic transsphenoidal surgery (ETS) and microscopic transsphenoidal surgery (MTS) are commonly applied treatments for patients with pituitary adenomas. This meta-analysis was conducted to evaluate the efficacy and safety of ETS and MTS for these patients.
methodsA computer search of Pubmed, Embase, Cochrane library, Web of Science, and Google Scholar databases was conducted for studies investigating ETS and MTS for patients with pituitary adenomas. The deadline is March 01, 2021. RevMan5.1 software was used to complete this meta-analysis after literature screening, data extraction, and literature quality evaluation.
resultsA total of 37 studies including 5,591 patients were included. There was no significant difference in gross tumor removal (GTR) and hormone-excess secretion remission (HES remission) between two groups [RR = 1.10, 95% CI (0.99-1.22),
conclusionThis meta-analysis indicated that ETS cannot significantly improve GTR and HES remission. However, ETS could reduce the incidence of DI, hypothyroidism, and septal perforation without increasing the rate of other complications. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/#myprospero, identifier: CRD42021241217.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.