Evidence map›Paper›PMID 35186798›Full record

ArticleFrontiers in cellular and infection microbiology2022

Dysregulation of Cytosolic c-di-GMP in

Ying Wen, Ying Wang, Shouwen Chen, Xiangshan Zhou, Yuanxing Zhang, Dahai Yang, Gabriel Núñez, Qin Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Recent progress in understanding ferroptosis mechanisms in infectious diseases.Frontiers in cellular and infection microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Ying WenState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Ying WangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Shouwen ChenState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Xiangshan ZhouState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Yuanxing ZhangSouthern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai, China.
Dahai YangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Gabriel NúñezDepartment of Pathology and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, United States.
Qin LiuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
East China University of Science and Technology · CNMichigan Center for Translational Pathology · USSouthern Marine Science and Engineering Guangdong Laboratory (Guangzhou) · CNUniversity of Michigan–Ann Arbor · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Programmed cell death plays an important role in modulating host immune defense and pathogen infection. Ferroptosis is a type of inflammatory cell death induced by intracellular iron-dependent accumulation of toxic lipid peroxides. Although ferroptosis has been associated with cancer and other sterile diseases, very little is known about the role of ferroptosis in modulating host-pathogen interactions. We show that accumulation of the secondary messenger bis-(3',5')-cyclic dimeric GMP (c-di-GMP) in the pathogenic bacterium

Indexed as

Enterobacteriaceae InfectionsFerroptosisBacterial ProteinsCyclic GMPEdwardsiellaHeLa CellsHumansVirulenceBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPbacterial virulencec-di-GMP accumulationEdwardsiella piscicidanon-canonical ferroptosispathogen infection

Identifiers

PMID35186798
PMCPMC8855483
OpenAlexW4210435343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.