Evidence map›Paper›PMID 35186711›Full record

ArticleFrontiers in oncology2021

The Role of the EZH2 and H3K27me3 Expression as a Predictor of Clinical Outcomes in Salivary Duct Carcinoma Patients: A Large-Series Study With Emphasis on the Relevance to the Combined Androgen Blockade and HER2-Targeted Therapy.

Natsuki Saigusa, Hideaki Hirai, Yuichiro Tada, Daisuke Kawakita, Masato Nakaguro, Kiyoaki Tsukahara, Satoshi Kano, Hiroyuki Ozawa, Takahito Kondo, Kenji Okami and 25 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 19 institutions in 1 country.

Natsuki SaigusaDepartment of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.
Hideaki HiraiDepartment of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.
Yuichiro TadaDepartment of Head and Neck Oncology and Surgery, International University of Health and Welfare, Mita Hospital, Tokyo, Japan.
Daisuke KawakitaDepartment of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Masato NakaguroDepartment of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.
Kiyoaki TsukaharaDepartment of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan.
Satoshi KanoDepartment of Otolaryngology Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Hiroyuki OzawaDepartment of Otorhinolaryngology Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
Takahito KondoDepartment of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan.
Kenji OkamiDepartment of Otolaryngology Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan.
Takafumi TogashiDepartment of Head and Neck Surgery, Niigata Cancer Center Hospital, Niigata, Japan.
Yukiko SatoDepartment of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Makoto UranoDepartment of Diagnostic Pathology Bantane Hospital Fujita Health University, School of Medicine, Nagoya, Japan.
Manami KajiwaraDepartment of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.
Tomotaka ShimuraDepartment of Otolaryngology, Showa University Fujigaoka Hospital, Yokohama, Japan.
Chihiro FushimiDepartment of Head and Neck Oncology and Surgery, International University of Health and Welfare, Mita Hospital, Tokyo, Japan.
Akira ShimizuDepartment of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan.
Isaku OkamotoDepartment of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan.
Takuro OkadaDepartment of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan.
Takayoshi SuzukiDepartment of Otolaryngology Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Yorihisa ImanishiDepartment of Otorhinolaryngology Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
Yoshihiro WatanabeDepartment of Otorhinolaryngology Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
Akihiro SakaiDepartment of Otolaryngology Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan.
Koji EbisumotoDepartment of Otolaryngology Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan.
Yuichiro SatoDepartment of Head and Neck Surgery, Niigata Cancer Center Hospital, Niigata, Japan.
Yoshitaka HonmaDepartment of Head and Neck, Esophageal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
Keisuke YamazakiDepartment of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Yushi UekiDepartment of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Toyoyuki HanazawaDepartment of Otolaryngology, Head and Neck Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Yuki SaitoDepartment of Otolaryngology - Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Hideaki TakahashiDepartment of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University, School of Medicine, Yokohama, Japan.
Mizuo AndoDepartment of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Shinji KohsakaDivision of Cellular Signaling, National Cancer Center Research Institute, Tokyo, Japan.
Takashi MatsukiDepartment of Otorhinolaryngology, Head and Neck Surgery, Kitasato University School of Medicine, Kanagawa, Japan.
Toshitaka NagaoDepartment of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.
Tokyo Medical University · JPKeio University · JPTokai University · JPHokkaido University · JPMita Hospital · JPNiigata Cancer Center Hospital · JPNiigata University · JPChiba University · JPFujita Health University · JPJapanese Foundation For Cancer Research · JPKitasato University · JPNagoya City University · JPNagoya University Hospital · JPNational Cancer Center Hospital East · JPOkayama University · JPShowa University Fujigaoka Hospital · JPThe University of Tokyo · JPTokyo Medical University Hachioji Medical Center · JPYokohama City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSalivary duct carcinoma (SDC) is a highly aggressive and uncommon tumor arising not only MATERIALS AND

methodsThe EZH2 and H3K27me3 immunohistochemical expression and

resultsEZH2 and H3K27me3 were variably immunoreactive in most SDCs. A positive correlation was found between the expression of EZH2 and H3K27me3. The EZH2 expression in the SDC component was significantly higher than that in the pre-existing pleomorphic adenoma component.

conclusionsA high expression of EZH2 and H3K27me3 in SDC might be a predictor of a poor efficacy of AR-targeted therapy. Our data provide new insights into the role of EZH2 and H3K27me3 in therapeutic strategies for SDC.

Indexed as

androgen receptorcombined androgen blockade (CAB)EZH2H3K27me3HER2prognosissalivary duct carcinomatherapeutic effect

Identifiers

PMID35186711
PMCPMC8850643
OpenAlexW4210301088

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.