Evidence map›Paper›PMID 35186473›Full record

ArticlePeerJ2022

From hair to liver: emerging application of hair follicle mesenchymal stem cell transplantation reverses liver cirrhosis by blocking the TGF-β/Smad signaling pathway to inhibit pathological HSC activation.

Qi Liu, Chengqian Lv, Yanan Jiang, Kunpeng Luo, Yang Gao, Jingyang Liu, Xu Zhang, Jan Mohammad Omar, Shizhu Jin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Qi Liu *Department of Gastroenterology and Hepatology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Chengqian Lv *Department of Gastroenterology and Hepatology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Yanan JiangDepartment of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy of Harbin Medical University, Harbin, China.
Kunpeng LuoDepartment of Gastroenterology and Hepatology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Yang GaoDepartment of Gastroenterology and Hepatology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Jingyang LiuDepartment of Gastroenterology and Hepatology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Xu ZhangDepartment of Gastroenterology and Hepatology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Jan Mohammad OmarDepartment of Gastroenterology and Hepatology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Shizhu JinDepartment of Gastroenterology and Hepatology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Harbin Medical University · CNSecond Affiliated Hospital of Harbin Medical University · CNHeilongjiang Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver cirrhosis (LC) involves multiple systems throughout the body, and patients with LC often die of multiple organ failure. However, few drugs are useful to treat LC. Hair follicle mesenchymal stem cells (HF-MSCs) are derived from the dermal papilla and the bulge area of hair follicles and are pluripotent stem cells in the mesoderm with broad prospects in regenerative medicine. As an emerging seed cell type widely used in skin wound healing and plastic surgery, HF-MSCs show considerable prospects in the treatment of LC due to their proliferation and multidirectional differentiation capabilities. We established an LC model in C57BL/6J mice by administering carbon tetrachloride (CCl

Indexed as

Mesenchymal Stem Cell TransplantationTransforming Growth Factor beta1AnimalsHairHair FollicleLiver CirrhosisMiceMice, Inbred C57BLSignal TransductionSmad ProteinsTransforming Growth Factor betaSmad ProteinsTransforming Growth Factor betaTransforming Growth Factor beta1DifferentiationHair follicle mesenchymal stem cellsHepatic stellate cellsHomingLiver cirrhosisTGF-β/Smad signaling pathway

Identifiers

PMID35186473
PMCPMC8855721
OpenAlexW4213227167

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.