Evidence map›Paper›PMID 35186303›Full record

ArticleCanadian journal of kidney health and disease2020

Stone Prevalence in Autosomal Dominant Polycystic Kidney Disease: A Systematic Review and Meta-Analysis.

Vinusha Kalatharan, Gary Grewal, Danielle M Nash, Blayne Welk, Sisira Sarma, York Pei, Amit X Garg

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of kidney health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Vinusha KalatharanDepartment of Epidemiology and Biostatistics, Western University, London, ON, Canada.ORCID https://orcid.org/0000-0001-7431-8087
Gary GrewalDepartment of Epidemiology and Biostatistics, Western University, London, ON, Canada.
Danielle M NashDepartment of Epidemiology and Biostatistics, Western University, London, ON, Canada.
Blayne WelkDepartment of Epidemiology and Biostatistics, Western University, London, ON, Canada.
Sisira SarmaDepartment of Epidemiology and Biostatistics, Western University, London, ON, Canada.
York PeiUniversity Health Network, University of Toronto, ON, Canada.
Amit X GargDepartment of Epidemiology and Biostatistics, Western University, London, ON, Canada.ORCID https://orcid.org/0000-0003-3398-3114
Western University · CAUniversity Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is uncertain how often patients with autosomal dominant polycystic kidney disease (ADPKD) develop kidney stones.

objectiveTo review English-language studies reporting the incidence and prevalence of stones and stone interventions in adults with ADPKD.

designSystematic review and meta-analysis.

settingAny country of origin. PATIENTS: Adult patients with ADPKD. MEASUREMENTS: Incidence or prevalence of kidney stones and stone interventions.

methodsWe reviewed 1812 citations from bibliographic databases, abstracted data from 49 eligible studies, and assessed methodological quality in duplicate. In some studies, the proportion of adults with ADPKD with the outcome were compared to adults without ADPKD; for these studies, prevalence risk ratios were calculated and pooled using a random effects model.

resultsWe identified 49 articles that met our review criteria. The methodological quality of many studies was limited (scores ranging from 2 to 14 out of 22, with a higher score indicating higher quality). No study clearly reported stone incidence, and in the cross-sectional studies, the definition of stones was often unclear. The prevalence of stones ranged from 3% to 59%, and a prevalence of stone interventions ranged from 1% to 8%; the average patient age at the time of assessment ranged from 26 to 61 years across the studies. Two studies reported a nonstatistically significant higher stone prevalence in patients with ADPKD compared to unaffected family members. Compared to unaffected family members, patients with ADPKD had a higher prevalence of kidney stones (6 cross-sectional studies; unadjusted prevalence ratio: 1.8; 95% confidence interval: 1.3 to 2.6; LIMITATIONS: Studies were limited to articles published in English.

conclusionsThe prevalence of kidney stones and stone interventions in adults with ADPKD remains uncertain. Future studies of higher methodological quality are needed to better characterize the incidence and prevalence of kidney stones in patients with ADPKD.

trial registrationWe did not register the protocol for this systematic review.

Indexed as

epidemiologykidney stonesobservational studypolycystic kidney diseaseprevalencestone interventionsystematic review

Identifiers

PMID35186303
PMCPMC8851145
OpenAlexW4248823944

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.