ArticleEvolution, medicine, and public health2022
Serial passage in an insect host indicates genetic stability of the human probiotic
Article in Evolution, medicine, and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The insect- and plant-associated lifestyles of Pseudomonas protegens CHA0 are preserved following serial passage through insect larvae.PLoS pathogens · 2026Article
- A Study on the Stability and Carbohydrate Metabolic Traits of Starter Cultures in Response to Continuous Subculturing.International journal of molecular sciences · 2026Article
- Safety Assessment of the Potential Probiotic Bacterium Limosilactobacillus fermentum J23 Using the Mexican Fruit Fly (Anastrepha ludens Loew, Diptera: Tephritidae) as a Novel In Vivo Model.Probiotics and antimicrobial proteins · 2024Article
- Antibacterial MccM as the Major Microcin inInternational journal of molecular sciences · 2023Article
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Authors and funding
6 authors.
Funding
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Abstract
BACKGROUND AND
objectivesThe probiotic METHODOLOGY: Using a serial passage approach, we orally introduced EcN to larvae of
resultsWe observed weak phenotypic differences between the ancestral EcN and both, beetle and flour passaged EcN lines, in motility and growth at 30°C, but neither any genetic changes, nor the expected increased persistence of the beetle-passaged lines. One of these lines displayed distinct morphological and physiological characteristics. CONCLUSIONS AND IMPLICATIONS: Our findings suggest that EcN remains rather stable during serial passage in an insect. Weak phenotypic changes in growth and motility combined with a lack of genetic changes indicate a certain degree of phenotypic plasticity of EcN. LAY SUMMARY: For studying adaptation of the human probiotic
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