Evidence map›Paper›PMID 35186240›Full record

ArticleJournal of healthcare engineering2022

LncRNA ABHD11-AS1 Participates in the Progression of Cervical Carcinoma by Targeting miR-1254 and Is the Key to the Diagnosis and Treatment of Cervical Carcinoma in the Future.

Duanrong Zhu, Qun Hao, Min Qian, Yuli Hu, Feifei Wu

Open access · hybridAbstract read
In one paragraph

Article in Journal of healthcare engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Duanrong ZhuDepartment of Obstetrics and Gynecology, General Hospital of the Eastern Theater Command, Nanjing 210002, Jiangsu, China.ORCID 0000-0001-7639-0584
Qun HaoDepartment of Obstetrics and Gynecology, General Hospital of the Eastern Theater Command, Nanjing 210002, Jiangsu, China.ORCID 0000-0002-4105-2187
Min QianDepartment of Obstetrics and Gynecology, General Hospital of the Eastern Theater Command, Nanjing 210002, Jiangsu, China.ORCID 0000-0003-0441-6364
Yuli HuDepartment of Obstetrics and Gynecology, General Hospital of the Eastern Theater Command, Nanjing 210002, Jiangsu, China.ORCID 0000-0003-0615-6877
Feifei WuDepartment of Obstetrics and Gynecology, General Hospital of the Eastern Theater Command, Nanjing 210002, Jiangsu, China.ORCID 0000-0002-7939-8669
Nanjing General Hospital of Nanjing Military Command · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical carcinoma is the most common gynecologic tumor in the clinic. The incidence of cervical carcinoma has been increasing in recent years, and the age of the affected population is showing a younger trend. Long-chain noncoding RNA (LncRNA) acts in the cell cycle. In cervical carcinoma, many studies have also confirmed the important role of LncRNA. LncRNA ABHD11-AS1 is one of the genes abnormally expressed in cervical carcinoma, but the specific situation has not been fully explained. This study intended to confirm whether LncRNA ABHD11-AS1 can be applied for the treatment of cervical carcinoma in the future. From January 2015 to January 2017, 72 cases of cervical carcinoma patients and 78 cases of healthy people during the same period in our hospital were selected for prospective analysis. ABHD11-AS1 and miR-1254 in serum and carcinoma tissues of cervical carcinoma patients were detected. In addition, human cervical carcinoma cells HeLa and CaSki were obtained to analyze the effects of interference with ABHD11-AS1 and miR-1254 on the biological behavior of cervical carcinoma cells. Finally, the correlation of ABHD11-AS1 with miR-1254 was verified by double fluorescein reporter enzyme and immunocoprecipitation. ABHD11-AS1 was upregulated, and miR-1254 was reduced in serum and carcinoma tissues of cervical carcinoma patients (

Indexed as

CarcinomaMicroRNAsRNA, Long NoncodingUterine Cervical NeoplasmsCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansSerine ProteasesABHD11 protein, humanMicroRNAsMIRN1254 microRNA, humanRNA, Long NoncodingSerine Proteases

Identifiers

PMID35186240
PMCPMC8853821
OpenAlexW4211047403

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.