ArticleFrontiers in plant science2021
Genome-Wide Association Analysis Coupled With Transcriptome Analysis Reveals Candidate Genes Related to Salt Stress in Alfalfa (
Article in Frontiers in plant science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Investigating the functions of glycosyl hydrolase family 1 in foxtail millet through an integrated genome-wide survey, expression profiling, and variation analysis.BMC plant biology · 2026Article
- Integrative Genome-Wide Association and Transcriptome Analyses Identify Candidate Genes for Salt Tolerance During Cotton Germination.Plants (Basel, Switzerland) · 2026Article
- Salinity gradients alter root-zone soil microbiome structure and nitrogen-related functional potential in alfalfa (Frontiers in plant science · 2026Article
- Elucidation of genetic architecture for aphid resistance in alfalfa (Medicago sativa) via genome-wide association study.BMC plant biology · 2025Article
- Deciphering the genetic basis of chlorophyll fluorescence parameters and vegetation indices under heat stress in blueberry.BMC plant biology · 2025Article
- Advances in basic biology of alfalfa (Horticulture research · 2025Article
- Comparative transcriptome analysis of differentially expressed genes of Medicago falcata L. breeding lines response to saline-alkaline stress.BMC plant biology · 2025Article
- Unveiling alfalfa root rot resistance genes through an integrative GWAS and transcriptome study.BMC plant biology · 2025Article
- Understanding abiotic stress in alfalfa: physiological and molecular perspectives on salinity, drought, and heavy metal toxicity.Frontiers in plant science · 2025Review
- Transcriptome Analysis for Salt-Responsive Genes in Two Different Alfalfa (Plants (Basel, Switzerland) · 2024Article
- MsSPL12 is a positive regulator in alfalfa (Medicago sativa L.) salt tolerance.Plant cell reports · 2024Article
- Article
- Multi-omics analysis of hexaploid triticale that show molecular responses to salt stress during seed germination.Frontiers in plant science · 2024Article
- Article
- Role of bZIP Transcription Factors in Plant Salt Stress.International journal of molecular sciences · 2023Review
- Transcriptome and GWAS Analyses Reveal Candidate Gene for Root Traits of Alfalfa during Germination under Salt Stress.International journal of molecular sciences · 2023Article
- Genome-Wide Identification and Phylogenetic and Expression Analyses of theInternational journal of molecular sciences · 2023Article
- Genome-Wide Identification and Expression Analysis of HSF Transcription Factors in Alfalfa (Plants (Basel, Switzerland) · 2022Article
- Genome-Wide Identification and Expression Analysis of theInternational journal of molecular sciences · 2022Article
- Genome-Wide Identification and Analysis of the NF-Y Transcription Factor Family Reveal Its Potential Roles in Salt Stress in Alfalfa (International journal of molecular sciences · 2022Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salt stress is the main abiotic factor affecting alfalfa yield and quality. However, knowledge of the genetic basis of the salt stress response in alfalfa is still limited. Here, a genome-wide association study (GWAS) involving 875,023 single-nucleotide polymorphisms (SNPs) was conducted on 220 alfalfa varieties under both normal and salt-stress conditions. Phenotypic analysis showed that breeding status and geographical origin play important roles in the alfalfa salt stress response. For germination ability under salt stress, a total of 15 significant SNPs explaining 9%-14% of the phenotypic variation were identified. For tolerance to salt stress in the seedling stage, a total of 18 significant SNPs explaining 12%-23% of the phenotypic variation were identified. Transcriptome analysis revealed 2,097 and 812 differentially expressed genes (DEGs) that were upregulated and 2,445 and 928 DEGs that were downregulated in the leaves and roots, respectively, under salt stress. Among these DEGs, many encoding transcription factors (TFs) were found, including
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