Evidence map›Paper›PMID 35185859›Full record

ArticleFrontiers in immunology2021

Characterization of Interplay Between Autophagy and Ferroptosis and Their Synergistical Roles on Manipulating Immunological Tumor Microenvironment in Squamous Cell Carcinomas.

Lijie Chen, Xing Niu, Xue Qiao, Sai Liu, Hongmei Ma, Xueqing Shi, Xuemei He, Ming Zhong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 92 citations in OpenAlex.

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  14. Characterization of the mFrontiers in immunology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lijie ChenDepartment of Stomatology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Xing NiuDepartment of Stomatology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Xue QiaoDepartment of Central Laboratory, School and Hospital of Stomatology, China Medical University, Liaoning Province Key Laboratory of Oral Disease, Shenyang, China.
Sai LiuDepartment of Oral Histopathology, School and Hospital of Stomatology, China Medical University, Liaoning Province Key Laboratory of Oral Disease, Shenyang, China.
Hongmei MaDepartment of Stomatology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Xueqing ShiDepartment of Stomatology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Xuemei HeDepartment of Stomatology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Ming ZhongDepartment of Stomatology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Xiamen University · CNChina Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Squamous cell carcinomas (SCCs) with shared etiology, histological characteristics, and certain risk factors represent the most common solid cancers. This study reports the crosstalk between autophagy and ferroptosis at the molecular level in SCCs, and their roles on the immunological tumor microenvironment (TME) of SCCs. Methods: In this study, the connections between autophagy and ferroptosis were characterized in SCCs by analyzing the associations between autophagy- and ferroptosis-related genes in mRNA expression and prognosis, protein-protein interactions and shared signaling pathways. Autophagy potential index (API) and ferroptosis potential index (FPI) of each tumor were quantified for reflecting autophagy and ferroptosis levels Results: There were close connections between autophagy and ferroptosis at the mRNA and protein levels and prognosis. Both shared cancer-related pathways. The API and FPI were separately developed based on prognostic autophagy- and ferroptosis-related genes. A high correlation between API and FPI was found in SCCs. Their interplay was distinctly associated with favorable prognosis, enhanced sensitivity to chemotherapy drugs (Sunitinib, Gefitinib, Vinblastine and Vorinostat), an inflamed TME and higher likelihood of response to immunotherapy in SCCs. Conclusion: This study is the first to provide a comprehensive analysis of the interplay between autophagy and ferroptosis and their synergistical roles on manipulating the immunological TME in SCCs. These findings indicated that the induction of autophagy and ferroptosis combined with immunotherapy might produce synergistically enhanced anti-SCCs activity.

Indexed as

Carcinoma, Squamous CellFerroptosisAutophagyHumansRNA, MessengerTumor MicroenvironmentRNA, Messengerautophagycrosstalkdrug resistanceferroptosisimmunityprognosissquamous cell carcinomastumor microenvironment

Identifiers

PMID35185859
PMCPMC8854375
OpenAlexW4210445064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.