Evidence map›Paper›PMID 35185795›Full record

ArticleFrontiers in endocrinology2022

Value of Contrast-Enhanced Ultrasound for Evaluation of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma.

Fengkai Fang, Yi Gong, Liyan Liao, Fei Ye, Zhongkun Zuo, Xiaodu Li, Qi Zhang, Kui Tang, Yan Xu, Rongsen Zhang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Fengkai FangDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
Yi GongDepartment of Thyroid Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
Liyan LiaoDepartment of Pathology, The Second Xiangya Hospital, Central South University, Changsha, China.
Fei YeDepartment of Thyroid Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
Zhongkun ZuoDepartment of Thyroid Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
Xiaodu LiDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
Qi ZhangDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
Kui TangDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
Yan XuDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
Rongsen ZhangDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
Sijie ChenDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
Chengcheng NiuDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
Second Xiangya Hospital of Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the study was to evaluate the diagnostic value of contrast-enhanced ultrasound (CEUS) in distinguishing between benign and malignant cervical lymph nodes (LNs) in patients with papillary thyroid carcinoma (PTC). Two hundred and one cervical LNs (157 metastatic from PTC and 44 benign) were evaluated using conventional ultrasonography (US) and CEUS before biopsy or surgery. Histopathology was used as the gold standard. We evaluated the size, long axis/short axis ratio (L/S), fatty hilum, hyper-echogenicity, calcification, cystic change, peripheral vascularity and CEUS parameters for each lymph nodule. The CEUS parameters included enhancement type, homogeneity, perfusion type, ring enhancement, peak intensity (PI) index and area under the curve (AUC) index. Univariate analysis demonstrated that compared with benign LNs, malignant LNs more frequently had L/S < 2, absence of a fatty hilum, presence of hyper-echogenicity, presence of calcification, peripheral vascularity, hyper-enhancement, heterogeneous enhancement, centripetal perfusion, ring enhancement, PI index > 1 and AUC index > 1 on preoperative US and CEUS. Binary logistic regression analysis demonstrated that hyper-enhancement, centripetal perfusion, and ring enhancement are independent CEUS characteristics related to malignant LNs for their differentiation from benign LNs (all p < 0.05). Our study indicated that preoperative CEUS characteristics may serve as a useful tool to identify malignant cervical LNs from benign cervical LNs.

Indexed as

Thyroid NeoplasmsContrast MediaHumansLymphatic MetastasisLymph NodesThyroid Cancer, PapillaryUltrasonographyContrast Mediabenign cervical lymph nodescervical lymph node metastasiscontrast-enhanced ultrasoundconventional ultrasoundpapillary thyroid carcinomas

Identifiers

PMID35185795
PMCPMC8850786
OpenAlexW4210521273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.