ArticleFrontiers in endocrinology2021
Uric Acid Mediated the Association Between BMI and Postmenopausal Breast Cancer Incidence: A Bidirectional Mendelian Randomization Analysis and Prospective Cohort Study.
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Linking Hyperuricemia to Cancer: Emerging Evidence on Risk and Progression.Current oncology reports · 2025Pooled it
- Uric acid enhances tumor stemness in breast cancer cells by upregulating GMPS.Molecular medicine reports · 2026Article
- Prognostic Role of Uric Acid-to-Albumin Ratio in Patients with Metastatic Breast Cancer Treated with CDK4/6 Inhibitors.Journal of clinical medicine · 2026Article
- Serum Uric Acid Levels and the Risk of Breast Cancer and Benign Breast Tumors: A Systematic Review and Meta-Analysis.Health science reports · 2026Article
- Serum uric acid and its metabolism-a vital factor in the inflammatory transformation of cancer.Journal of advanced research · 2026Review
- Prognostic value of serum uric acid levels following radiotherapy and chemotherapy in nasopharyngeal carcinoma.Molecular and clinical oncology · 2026Article
- Relationship of women's breast nodules with lifestyle, mental health and metabolic characteristics: a large, retrospective, longitudinal cohort study.BMC public health · 2026Article
- Development and validation of a risk prediction model for postoperative frailty in breast cancer patients.PeerJ · 2026Article
- Machine learning-based association analysis of triglyceride-glucose index with melanoma prevalence and all-cause mortality: insights from cross-sectional NHANES 1999-2018 data and an external hospital-based dataset.Frontiers in nutrition · 2026Article
- Mendelian randomization analysis of modifiable risk factors for breast cancer.Discover oncology · 2025Review
- Investigating the relationship between body mass index, hypertension, and new-onset hyperuricemia in a Chinese repeat health checkup population.BMC public health · 2025Article
- The mediating roles of anthropo-metabolic biomarkers on the association between beverage consumption and breast cancer risk.Nutrition journal · 2025Article
- Association between serum urate levels, gout and breast cancer: observational and Mendelian randomization analyses.Translational cancer research · 2025Article
- Interplay between BMI, neutrophil, triglyceride and uric acid: a case-control study and bidirectional multivariate mendelian randomization analysis.Nutrition & metabolism · 2025Article
- Key factors determination of hyperuricemia and association analysis among patients with breast cancer: results from NHANES data.Frontiers in nutrition · 2025Article
- Discrimination of superficial lymph nodes using ultrasonography and tissue metabolomics coupled with machine learning.Frontiers in oncology · 2025Article
- Causal relationship between hepatic function indicators and thrombocytopenia risk in early-stage hepatitis B virus infection: evidence from clinical observational studies and mendelian randomization analyses.Frontiers in immunology · 2025Observational
- The causal relationship between androgenetic alopecia and serum uric acid: A bidirectional Mendelian randomization analysis.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- The 100 top-cited articles in menopausal syndrome: a bibliometric analysis.Reproductive health · 2024Article
- Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies.Med (New York, N.Y.) · 2024Article
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Observational epidemiological studies have reported the associations of high body mass index (BMI) with elevated serum uric acid (UA) level and increased risk of postmenopausal breast cancer. However, whether UA is causally induced by BMI and functioned in the BMI-breast cancer relationship remains unclear. Methods: To elucidate the causality direction between BMI and serum UA, the bidirectional Mendelian randomization (MR) analyses were performed by using summarized data from the largest Asian genome-wide association studies (GWAS) of BMI and UA carried out in over 150,000 Japanese populations. Then, a total of 19,518 postmenopausal women from the Dongfeng-Tongji (DFTJ) cohort (with a mean 8.2-year follow-up) were included and analyzed on the associations of BMI and serum UA with incidence risk of postmenopausal breast cancer by using multivariable Cox proportional hazard regression models. Mediation analysis was further conducted among DFTJ cohort to assess the intermediate role of serum UA in the BMI-breast cancer association. Results: In the bidirectional MR analyses, we observed that genetically determined BMI was causally associated with elevated serum UA [β(95% CI) = 0.225(0.111, 0.339), Conclusions: The current findings revealed a causal effect of BMI on increasing serum UA and highlighted the mediating role of UA in the BMI-breast cancer relationship. Controlling the serum level of UA among overweight postmenopausal women may help to decrease their incident risk of breast cancer.
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