ReviewFrontiers in neurology2022
Hypertension and Cognitive Impairment: A Review of Mechanisms and Key Concepts.
Review in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
93 citing papers in PubMed, 4 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Associations of Blood Pressure Parameters with Cognitive Decline and Dementia: A Systematic Review of Reviews.American journal of hypertension · 2026Pooled it
- Metformin and Cognitive Performance in Patients With Type 2 Diabetes: An Umbrella Review.Neuropsychopharmacology reports · 2025Pooled it
- Frontiers and hotspot evolution in research on Alzheimer's disease and hypertension: a bibliometric analysis from 2004 to 2023.Frontiers in neurology · 2025Pooled it
- Prevalence and risk factors of cognitive impairment in Chinese patients with hypertension: a systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Alterations of White Matter Connectivity in Adults with Essential Hypertension.International journal of general medicine · 2024Trial
- Nailfold Microvascular Abnormalities Are Associated with the Standardized In-Hospital Blood-Pressure Phenotype and Carotid Wall Thickness in Treated Hypertension: An Integrated Vascular Phenotyping Study.Journal of clinical medicine · 2026Article
- Temporal Mapping of CSVD-Related White Matter Lesions and Concurrent Neurovascular Dysfunction in Spontaneously Hypertensive Rats.CNS neuroscience & therapeutics · 2026Article
- Structure- and Ligand-Based Discovery of Novel Non-Arginine-Based DDAH1 Inhibitors with Anti-Triple-Negative Breast Cancer Activity.ACS medicinal chemistry letters · 2026Article
- Prediction of cognitive test scores: a comparison of brain structure, health, demographic, and cognitive data across adulthood.GeroScience · 2026Article
- Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson Laboratory.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Characterizing Alzheimer's Disease and Related Dementia in a Hypertension Population Within the State of Florida Using Electronic Health Record-Based Data.Clinical pharmacology and therapeutics · 2026Article
- Article
- Fruit and Vegetable Consumption and Its Public Health Implications for Hypertension Among Peruvian Aged 15 Years and Older: Evidence from the 2022-2023 Demographic and Health Survey.Healthcare (Basel, Switzerland) · 2026Article
- Cortical thinning and volumetric alterations in patients with unruptured intracranial aneurysms: insights from surface-based morphometry.Neurosurgical review · 2026Article
- Disparate Mechanical and Functional Properties of Spontaneously Hypertensive Rat and Spontaneously Hypertensive Heart Failure Rat Penetrating Arterioles.Journal of cardiovascular pharmacology · 2026Article
- Assessment of cognition and molecular markers for neuropsychological functions in hypertension.Journal of family medicine and primary care · 2026Article
- Impact of long-term systolic blood pressure on cognitive disorder risk: Across different age groups and antihypertensive medication timing.Journal of Alzheimer's disease : JAD · 2026Observational
- Defining the Intestinal eCBome and Oxylipin Signaling Systems in a TDP-43 Mouse Model of Frontotemporal Dementia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Investigating the dynamic association of multiple risk factors on cognitive impairment in older people: a retrospective cohort study in Baisha Town, Hepu County, China.BMC geriatrics · 2026Article
- Arterial Hypertension as a Modulator of Cognitive Response to CPAP Therapy in Moderate-to-Severe Obstructive Sleep Apnea.Medicina (Kaunas, Lithuania) · 2026Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive impairment, and dementia, are major contributors to global burden of death and disability, with projected increases in prevalence in all regions of the world, but most marked increases in low and middle-income countries. Hypertension is a risk factor for both Vascular Cognitive Impairment and Alzheimer's disease, the two most common causes of dementia, collectively accounting for 85% of cases. Key end-organ pathological mechanisms, for which hypertension is proposed to be causative, include acute and covert cerebral ischemia and hemorrhage, accelerated brain atrophy, cerebral microvascular rarefaction and endothelial dysfunction, disruption of blood-brain barrier and neuroinflammation that affects amyloid pathologies. In addition to the direct-effect of hypertension on brain structure and microvasculature, hypertension is a risk factor for other diseases associated with an increased risk of dementia, most notably chronic kidney disease and heart failure. Population-level targets to reduce the incidence of dementia are a public health priority. Meta-analyses of blood pressure lowering trials report a significant reduction in the risk of dementia, but the relative (7-11%) and absolute risk reductions (0.4% over 4 years) are modest. However, given the high lifetime prevalence of both conditions, such relative risk reduction would translate into important population-level reductions in dementia globally with effective screening and control of hypertension. Optimal blood pressure target, especially in older adults with orthostatic hypotension, and antihypertensive agent(s) are uncertain. In this review article, we will detail the observational and interventional evidence linking hypertension with cognitive impairment, summarizing the mechanisms through which hypertension causes cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.