ArticleFrontiers in neurology2022
The Triglyceride Glucose Index Is a Risk Factor for Enlarged Perivascular Space.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 21 citations in OpenAlex.
- Insulin resistance in cerebral small vessel disease: a mini review.Frontiers in neuroscience · 2026Review
- The triglyceride-glucose index: updating evidence from clinical settings to molecular mechanisms in ageing-related cerebrovascular diseases.Cardiovascular diabetology · 2025Review
- Correlation Between Blood Glucose Level and Cerebral Small Vessel Disease Markers in Neurologically Asymptomatic, Nondiabetic Individuals.Aging medicine (Milton (N.S.W)) · 2025Article
- Pathways from insulin resistance to incident cardiovascular disease: a Bayesian network analysis.Cardiovascular diabetology · 2024Article
- Novel inflammatory and insulin resistance indices provide a clue in cerebral amyloid angiopathy.Scientific reports · 2024Article
- A Closer Look at the Perivascular Unit in the Development of Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 Diabetes Mellitus.Biomedicines · 2024Review
- Effects of sleep on brain perivascular space in a cognitively healthy population.Sleep medicine · 2023Article
- Why Are Perivascular Spaces Important?Medicina (Kaunas, Lithuania) · 2023Review
- Application of machine learning model to predict lacunar cerebral infarction in elderly patients with femoral neck fracture before surgery.BMC geriatrics · 2022Article
- Association of triglyceride-glucose index with ischemic stroke recurrence in nondiabetic patients with small vessel occlusion: a multicenter hospital-based prospective cohort study.Cardiovascular diabetology · 2022Article
- Association of Dilated Perivascular Spaces With Lipid Indices in Ischemic Stroke Patients.Cureus · 2022Article
- Triglyceride glucose index is associated with cerebral small vessel disease burden and cognitive impairment in elderly patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The triglyceride glucose (TyG) index is considered a simple surrogate marker for insulin resistance and has been associated with cerebrovascular diseases. However, limited information is available regarding its association with the subclinical cerebral small vessel disease (CSVD). Here, we investigated the association of TyG index with the burden and distribution of enlarged perivascular space (EPVS) in the non-diabetic population. The data of 531 non-diabetic patients from 2017 to 2020 were assessed. Participants were grouped according to the burden of EPVS. TyG index was calculated using the log scale of fasting triglycerides (mg/dl) × fasting glucose (mg/dl)/2. The association of TyG index with EPVS burden and distribution was evaluated. In the multivariable logistic regression analysis, the TyG index was associated with moderate to severe EPVS [odds ratio (OR): 2.077; 95%
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