Evidence map›Paper›PMID 35185755›Full record

ArticleFrontiers in neurology2021

Daily Remote Ischemic Conditioning Can Improve Cerebral Perfusion and Slow Arterial Progression of Adult Moyamoya Disease-A Randomized Controlled Study.

Jiali Xu, Qian Zhang, Gary B Rajah, Wenbo Zhao, Fang Wu, Yuchuan Ding, Bowei Zhang, Wenting Guo, Qi Yang, Xiurong Xing and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  4. Trial
  5. Review
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  7. Review
  8. Neuroadaptive Biochemical Mechanisms of Remote Ischemic Conditioning.International journal of molecular sciences · 2023
    Review
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Jiali XuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Qian ZhangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Gary B RajahDepartment of Neurosurgery, Wayne State University, Detroit, MI, United States.
Wenbo ZhaoDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Fang WuDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yuchuan DingDepartment of Neurosurgery, Wayne State University, Detroit, MI, United States.
Bowei ZhangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Wenting GuoDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Qi YangDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Xiurong XingBeijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Sijie LiLaboratory of Brain Disorders, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China.
Xunming JiLaboratory of Brain Disorders, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China.
Capital Medical University · CNChinese Institute for Brain Research · CNWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeMoyamoya disease (MMD) is a complicated cerebrovascular disease with recurrent ischemic or hemorrhagic events. This study aimed to prove the safety and efficacy of remote ischemic conditioning (RIC) on MMD.

methodsIn total, 34 patients with MMD participated in this pilot, prospective randomized controlled study for 1 year. 18 patients were allocated into the RIC group, and 16 patients accepted routine medical treatment only. RIC-related adverse events were recorded. The primary outcome was the improvement ratio of mean cerebral blood flow (mCBF) in middle cerebral artery territory measured by multidelay pseudocontinuous arterial spin labeling, and the secondary outcomes were the cumulative incidence of major adverse cerebrovascular events (MACEs), the prevalence of stenotic-occlusive progression, and periventricular anastomosis at 1-year follow-up.

resultsIn total, 30 of the 34 patients with MMD completed the final follow-up (17 in the RIC group and 13 in the control group). No adverse events of RIC were observed. The mCBF improvement ratio of the RIC group was distinctively higher compared with the control group (mCBF

conclusionsRemote ischemic conditioning has the potential to be a safe and effective adjunctive therapy for patients with MMD largely due to improving cerebral blood flow and slowing the arterial progression of the stenotic-occlusive lesions. These findings warrant future studies in larger trials.

Indexed as

arterial spin labeling (ASL)cerebral blood flowmoyamoya diseaseremote ischemic conditioningstroke

Identifiers

PMID35185755
PMCPMC8850829
OpenAlexW4210550502

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.