Evidence map›Paper›PMID 35185654›Full record

ArticleFrontiers in psychiatry2022

Habenular Involvement in Response to Subcallosal Cingulate Deep Brain Stimulation for Depression.

Gavin J B Elias, Jürgen Germann, Aaron Loh, Alexandre Boutet, Aditya Pancholi, Michelle E Beyn, Venkat Bhat, D Blake Woodside, Peter Giacobbe, Sidney H Kennedy and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Gavin J B EliasDivision of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, ON, Canada.
Jürgen GermannDivision of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, ON, Canada.
Aaron LohDivision of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, ON, Canada.
Alexandre BoutetDivision of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, ON, Canada.
Aditya PancholiDivision of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, ON, Canada.
Michelle E BeynDivision of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, ON, Canada.
Venkat BhatCentre for Mental Health and Krembil Research Centre, University Health Network, Toronto, ON, Canada.
D Blake WoodsideCentre for Mental Health, University Health Network, Toronto, ON, Canada.
Peter GiacobbeDepartment of Psychiatry, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, ON, Canada.
Sidney H KennedyCentre for Mental Health, University Health Network, Toronto, ON, Canada.
Andres M LozanoDivision of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, ON, Canada.
University of Toronto · CAUniversity Health Network · CAKrembil Foundation · CASunnybrook Health Science Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The habenula (Hb) is a small, evolutionarily conserved epithalamic structure implicated in functions such as reward and mood regulation. Prior imaging work suggests that Hb's structural and functional properties may relate to treatment response in depression and other mood disorders. We used multimodal MRI techniques to investigate the potential involvement of Hb in response to subcallosal cingulate area deep brain stimulation (SCC-DBS) for treatment-resistant mood disorders. Using an automated segmentation technique, we compared Hb volume at baseline and at a subsequent post-operative timepoint (4.4 ± 3.0 years after surgery) in a cohort of 32 patients who received SCC-DBS. Clinical response to treatment (≥50% decrease in HAMD-17 from baseline to 12 months post-operation) was significantly associated with longitudinal Hb volume change: responders tended to have increased Hb volume over time, while non-responders showed decreased Hb volume (

Indexed as

deep brain stimulationdepressionhabenulaneuroimagingneuromodulationtreatment biomarker

Identifiers

PMID35185654
PMCPMC8854862
OpenAlexW4210697984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.