Evidence map›Paper›PMID 35185611›Full record

ArticleFrontiers in physiology2022

Chronic, Combined Cardiac and Renal Dysfunction Exacerbates Renal Venous Pressure-Induced Suppression of Renal Function in Rats.

Shereen M Hamza, Xiaohua Huang, Tayyaba Zehra, Wenqing Zhuang, William A Cupples, Branko Braam

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Shereen M HamzaDivision of Nephrology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Xiaohua HuangDivision of Nephrology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Tayyaba ZehraDivision of Nephrology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Wenqing ZhuangDivision of Nephrology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
William A CupplesBiomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
Branko BraamDivision of Nephrology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
University of Alberta · CASimon Fraser University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveIncreased renal venous pressure (RVP) is common in combined heart and kidney failure. We previously showed that acute RVP elevation depresses renal blood flow (RBF), glomerular filtration rate (GFR), and induces renal vasoconstriction in the absence of changes in blood pressure in healthy rats. We used our established rodent model of chronic combined heart and kidney failure (H/KF) to test whether RVP elevation would impair cardiovascular stability, renal perfusion and exacerbate renal dysfunction.

methodsMale rats were subjected to 5/6 nephrectomy (SN

resultsBaseline MAP, HR, RBF, and renal vascular conductance (RVC) were comparable among groups. Baseline GFR was significantly depressed in CL + SN

conclusionChronic combined heart and kidney failure primarily impairs renal hemodynamic stability in response to elevated RVP compared to healthy rats.

Indexed as

blood pressurecombined cardiac and renal dysfunctionglomerular filtration raterenal blood flowrenal venous congestion

Identifiers

PMID35185611
PMCPMC8854789
OpenAlexW4210541858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.