Evidence map›Paper›PMID 35185548›Full record

ArticleFrontiers in pharmacology2021

A Comparison of Intranasal Dexmedetomidine, Esketamine or a Dexmedetomidine-Esketamine Combination for Induction of Anaesthesia in Children: A Randomized Controlled Double-Blind Trial.

Xinlei Lu, Ling Tang, Haiyan Lan, Chunli Li, Han Lin

5 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06613243 phase4completednot on this mapstarted 2024, after this paper: background citation

Different Doses of Dexmedetomidine Combined With Esketamine for Analgesia in Women Undergoing Cesarean Delivery: a Pilot Randomized Trial

TypeinterventionalSponsorPeking University First HospitalRan2024 to 2024Enrolled120ConditionsCesarean Delivery, Esketamine, Neuropsychiatric Symptoms, DexmedetomidineArmsEsketamine 0.2 mg/kg, Esketamine 0.2 mg/kg + dexmedetomidine 0.1 µg/kg, Esketamine 0.2 mg/kg + dexmedetomidine 0.15 µg/kg, Esketamine 0.2 mg/kg + dexmedetomidine 0.2 µg/kg
NCT07576517 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Perioperative Use of Dexmedetomidine-esketamine Combination and Transcranial Direct Current Stimulation for Prevention of Neurocognitive Complications in Older Patients After Non-cardiac Surgery: a 2×2 Factorial Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2030Enrolled1,160ConditionsOlder Patients, Surgery, Dexmedetomidine, EsketamineArmsDex-Esk, Placebo, Active tDCS, Sham tDCS
NCT07576543 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Long-term Follow-up of Perioperative Dexmedetomidine-esketamine Combination and Transcranial Direct Current Stimulation for Prevention of Neurocognitive Complications in Older Patients After Non-cardiac Surgery

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2031Enrolled1,160ConditionsOlder Patients, Surgery, Dexmedetomidine, EsketamineArmsDex-Esk, Placebo, Active tDCS, Sham tDCS
NCT07610343 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Impact of Intranasal Dexmedetomidine-esketamine on Sleep Quality and Cognitive Function in Older Adults With Mild-to-moderate Cognitive Impairment: a Randomized, Double-blind, and Placebo-controlled Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2027Enrolled60ConditionsOlder Adults, Cognitive Impairment, Sleep Disorders, DexmedetomidineArmsDexmedetomidine-esketamine combination, Placebo
NCT07639099 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Impact of Intranasal Esketamine-dexmedetomidine Combination on Postpartum Depression in Parturients With Prenatal Depressive Symptoms: a Randomized, Double-blind, and Placebo-controlled Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2029Enrolled164ConditionsParturients, Depressive Symptoms, Esketamine, DexmedetomidineArmsEsketamine-dexmedetomidine combination, Placebo
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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  18. Clinical applications of esketamine: Current status and future perspectives.The Journal of international medical research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xinlei LuDepartment of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Ling TangDepartment of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Haiyan LanDepartment of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Chunli LiDepartment of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Han LinDepartment of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Wenzhou Medical University · CNSecond Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

childrendexmedetomidineesketamineintranasal administrationpreoperative sedation

Identifiers

PMID35185548
PMCPMC8848099
OpenAlexW4210669115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.