ArticleFrontiers in aging neuroscience2022
Increased RNA Transcription of Energy Source Transporters in Circulating White Blood Cells of Aged Mice.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Article
- GLUT1 and GLUT3 in brain glucose metabolism: mechanisms, regulation, and implications for metabolic disorders.Metabolic brain disease · 2025Review
- Article
- Leukocytes and Endothelial Cells Participate in the Pathogenesis of Alzheimer's Disease: Identifying New Biomarkers Mirroring Metabolic Alterations.Journal of Alzheimer's disease : JAD · 2024Article
- RNA Analysis of Circulating Leukocytes in Patients with Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Article
- Activation of neurogenesis in the hippocampus is a novel therapeutic target for Alzheimer's disease.Neuroprotection (Chichester, England) · 2023Article
- Cell Therapies for Autism Spectrum Disorder Based on New Pathophysiology: A Review.Cell transplantationReview
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
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Abstract
Circulating white blood cells (WBC) contribute toward maintenance of cerebral metabolism and brain function. Recently, we showed that during aging, transcription of metabolism related genes, including energy source transports, in the brain significantly decreased at the hippocampus resulting in impaired neurological functions. In this article, we investigated the changes in RNA transcription of metabolism related genes (glucose transporter 1 [Glut1], Glut3, monocarboxylate transporter 4 [MCT4], hypoxia inducible factor 1-α [Hif1-α], prolyl hydroxylase 3 [PHD3] and pyruvate dehydrogenase kinase 1 [PDK1]) in circulating WBC and correlated these with brain function in mice. Contrary to our expectations, most of these metabolism related genes in circulating WBC significantly increased in aged mice, and correlation between their increased RNA transcription and impaired neurological functions was observed. Bone marrow mononuclear transplantation into aged mice decreased metabolism related genes in WBC with accelerated neurogenesis in the hippocampus.
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