Evidence map›Paper›PMID 35185321›Full record

ArticleIEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division2022

MR-Tracked Deflectable Stylet for Gynecologic Brachytherapy.

Anthony L Gunderman, Ehud J Schmidt, Marc Morcos, Junichi Tokuda, Ravi T Seethamraju, Henry R Halperin, Akila N Viswanathan, Yue Chen

Open access · greenAbstract read
In one paragraph

Article in IEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  3. Modeling and Control of an MR-Safe Pneumatic Radial Inflow Motor and Encoder (PRIME).IEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division · 2024
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  5. MRI-Conditional Eccentric-Tube Injection Needle: Design, Fabrication, and Animal Trial.IEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division · 2023
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  6. Review of Robot-Assisted HIFU Therapy.Sensors (Basel, Switzerland) · 2023
    Review
  7. Open Source MR-Safe Pneumatic Radial Inflow Motor and Encoder (PRIME): Design and Manufacturing Guidelines.... International Symposium on Medical Robotics. International Symposium on Medical Robotics · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Anthony L GundermanMechanical Engineering Department, University of Arkansas, Fayetteville, AR 72701 USA.
Ehud J SchmidtDepartment of Medicine, Johns Hopkins University, Baltimore, MD., 21205.
Marc MorcosDepartment of Radiation Oncology, Johns Hopkins University, Baltimore, MD., 21205.
Junichi TokudaDepartment of Radiology, Harvard Medical School, Boston, MA., 02115.
Ravi T SeethamrajuSiemens Healthineers Boston, Boston, MA, 02115.
Henry R HalperinDepartment of Medicine, Johns Hopkins University, Baltimore, MD., 21205.
Akila N ViswanathanDepartment of Radiation Oncology, Johns Hopkins University, Baltimore, MD., 21205.
Yue ChenMechanical Engineering Department, University of Arkansas, Fayetteville, AR 72701 USA.
Johns Hopkins University · USUniversity of Arkansas at Fayetteville · USHarvard University · USSiemens Healthcare (United States) · US

Funding

Improved Targeting and Assessment of Electrophysiology InterventionR01HL094610 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HALPERIN, HENRY R · 2009 to 2018
$15.5M
The Pathophysiology and Therapy of Pulseless Electrical ActivityR01HL126092 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HALPERIN, HENRY R · 2015 to 2018
$2.8M
Multiparametric Magnetic Resonance Imaging as a Novel Approach to Brachytherapy for Cervical CancerR01CA237005 · NCI · JOHNS HOPKINS UNIVERSITY · PI VISWANATHAN, AKILA · 2020 to 2024
$2.8M
MR Image Guided Gynecologic BrachytherapyR21CA167800 · NCI · JOHNS HOPKINS UNIVERSITY · PI VISWANATHAN, AKILA · 2013 to 2014
$394k
NCI NIH HHS R01 CA237005NCI NIH HHS R21 CA167800NHLBI NIH HHS R01 HL094610NHLBI NIH HHS R01 HL126092
6 · The paper itself

Abstract

Brachytherapy is a radiation based treatment that is implemented by precisely placing focused radiation sources into tumors. In advanced interstitial cervical cancer bracytherapy treatment, this is performed by placing a metallic rod ("stylet") inside a hollow cylindrical tube ("catheter") and advancing the pair to the desired target. The stylet is removed once the target is reached, followed by the insertion of radiation sources into the catheter. However, manually advancing an initially straight stylet into the tumor with millimeter spatial accuracy has been a long-standing challenge, which requires multiple insertions and retractions, due to the unforeseen stylet deflection caused by the stiff muscle tissue that is traversed. In this paper, we develop a novel tendon-actuated deflectable stylet equipped with MR active-tracking coils that may enhance brachytherapy treatment outcomes by allowing accurate stylet trajectory control. Herein we present the design concept and fabrication method, followed by the kinematic and mechanics models of the deflectable stylet. The hardware and theoretical models are extensively validated via benchtop and MRI-guided characterization. At insertion depths of 60 mm, benchtop phantom targeting tests provided a targeting error of 1. 23 ± 0. 47 mm, and porcine tissue targeting tests provided a targeting error of 1. 65 ± 0. 64 mm, after only a single insertion. MR-guided experiments indicate that the stylet can be safely and accurately located within the MRI environment.

Indexed as

BrachytherapyDeflectable StyletMR trackingTendon-driven

Identifiers

PMID35185321
PMCPMC8855967
OpenAlexW3135365533

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.