Evidence map›Paper›PMID 35184757›Full record

ReviewBreast cancer research : BCR2022

Artificial intelligence in mammographic phenotyping of breast cancer risk: a narrative review.

Aimilia Gastounioti, Shyam Desai, Vinayak S Ahluwalia, Emily F Conant, Despina Kontos

Registry-linked trialAbstract readReview
In one paragraph

Review in Breast cancer research : BCR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06629896 (Comparison Between Contrast-Enhanced Mammography and Magnetic Resonance Imaging in the Surveillance of High-Risk Women for Breast Cancer), which is not on this map. Cited by 45 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06629896 narecruitingnot on this mapstarted 2025, after this paper: background citation

Comparison Between Contrast-Enhanced Mammography and Magnetic Resonance Imaging in the Surveillance of High-Risk Women for Breast Cancer: The Randomized Controlled Trial 'Con-trust. Funded by European Commission NextGenerationEU - Ministero Della Salute PNRR: M6/C2_CALL 2023 Full Proposal

TypeinterventionalSponsorAzienda USL Reggio Emilia - IRCCSRan2025 to 2030Enrolled2,200ConditionsBreast Cancer Screening and DiagnosisArmsContrast Enhancement Mammography, magnetic resonance imaging (MRI) and digital mammography (DM)
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aimilia GastouniotiDepartment of Radiology, Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, 19104, USA.
Shyam DesaiDepartment of Radiology, Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, 19104, USA.
Vinayak S AhluwaliaDepartment of Radiology, Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, 19104, USA.
Emily F ConantDepartment of Radiology, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Despina KontosDepartment of Radiology, Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, PA, 19104, USA. Despina.Kontos@pennmedicine.upenn.edu.ORCID 0000-0001-9031-5126

Funding

Effect of Breast Density on Screening Recall with Digital Breast TomosynthesisR01CA161749 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KONTOS, DESPINA · 2012 to 2021
$3.6M
Automated Density Measures for Estimating Breast Cancer Risk and Therapy ResponseR01CA177150 · NCI · MAYO CLINIC ROCHESTER · PI KERLIKOWSKE, KARLA M, VACHON, CELINE M · 2013 to 2017
$3.0M
NCI NIH HHS R01 CA161749NCI NIH HHS R01 CA177150
6 · The paper itself

Abstract

backgroundImproved breast cancer risk assessment models are needed to enable personalized screening strategies that achieve better harm-to-benefit ratio based on earlier detection and better breast cancer outcomes than existing screening guidelines. Computational mammographic phenotypes have demonstrated a promising role in breast cancer risk prediction. With the recent exponential growth of computational efficiency, the artificial intelligence (AI) revolution, driven by the introduction of deep learning, has expanded the utility of imaging in predictive models. Consequently, AI-based imaging-derived data has led to some of the most promising tools for precision breast cancer screening. MAIN BODY: This review aims to synthesize the current state-of-the-art applications of AI in mammographic phenotyping of breast cancer risk. We discuss the fundamentals of AI and explore the computing advancements that have made AI-based image analysis essential in refining breast cancer risk assessment. Specifically, we discuss the use of data derived from digital mammography as well as digital breast tomosynthesis. Different aspects of breast cancer risk assessment are targeted including (a) robust and reproducible evaluations of breast density, a well-established breast cancer risk factor, (b) assessment of a woman's inherent breast cancer risk, and (c) identification of women who are likely to be diagnosed with breast cancers after a negative or routine screen due to masking or the rapid and aggressive growth of a tumor. Lastly, we discuss AI challenges unique to the computational analysis of mammographic imaging as well as future directions for this promising research field.

conclusionsWe provide a useful reference for AI researchers investigating image-based breast cancer risk assessment while indicating key priorities and challenges that, if properly addressed, could accelerate the implementation of AI-assisted risk stratification to future refine and individualize breast cancer screening strategies.

Indexed as

Artificial IntelligenceBreast NeoplasmsEarly Detection of CancerFemaleHumansMammographyArtificial intelligenceBreast cancerBreast cancer riskBreast densityBreast tomosynthesisDeep learningDigital mammographyMammographic densityMammographic imaging

Identifiers

PMID35184757
PMCPMC8859891

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.