ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022
Poor pulmonary function is associated with mild cognitive impairment, its progression to dementia, and brain pathologies: A community-based cohort study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Cognitive impairment in chronic respiratory disease patients using long-term oxygen therapy: a narrative review.Medical gas research · 2026Review
- Association between intrinsic capacity and chronic lung disease among middle-aged and older adults: evidence from CHARLS and ELSA.BMC public health · 2026Article
- Impaired lung function is associated with elevated blood biomarkers of AD/ADRD: unraveling the interplay with risk of dementia.Scientific reports · 2026Article
- Association of the Planetary Health Diet with dementia risk and brain pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Impaired lung function is associated with elevated blood biomarkers of AD/ADRD: Unraveling the interplay with risk of dementia.Research square · 2025Article
- Association of pulmonary function with the risk of incident Alzheimer's disease: a prospective cohort and Mendelian randomization study.Aging clinical and experimental research · 2025Article
- Pulmonary function and motoric cognitive risk syndrome in older adults.Scientific reports · 2025Article
- Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer's disease.Nature communications · 2025Article
- Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances.Signal transduction and targeted therapy · 2025Review
- Influence of lung function on macro- and micro-structural brain changes in mid- and late-life.International journal of surgery (London, England) · 2025Article
- Peak expiratory flow predicts motoric cognitive risk syndrome: A cohort study.Journal of the American Geriatrics Society · 2025Article
- Profile of non-invasive physical health indicators associated with cognitive performance in Chinese older adults: evidence from the China Health and Retirement Longitudinal Study.BMC public health · 2025Article
- Association between pulmonary ventilation function and cognitive function among middle-aged and older adults: an observational study from Southwest China.BMC pulmonary medicine · 2024Observational
- The Link Between Paraquat and Demyelination: A Review of Current Evidence.Antioxidants (Basel, Switzerland) · 2024Review
- Lung function in relation to brain aging and cognitive transitions in older adults: A population-based cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Lung inflammation induced by silica particles triggers hippocampal inflammation, synapse damage and memory impairment in mice.Journal of neuroinflammation · 2022Article
- Poor pulmonary function is associated with mild cognitive impairment, its progression to dementia, and brain pathologies: A community-based cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Development of a novel dementia risk prediction model in the general population: A large, longitudinal, population-based machine-learning study.EClinicalMedicine · 2022Article
- Association between pulmonary ventilatory function and mild cognitive impairment: A population-based study in rural China.Frontiers in public health · 2022Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
introductionThe relationship between pulmonary function (PF) and mild cognitive impairment (MCI), dementia, and brain pathologies remains unclear.
methodsA total of 1312 dementia-free participants, including a cognitively intact group (n = 985) and an MCI group (n = 327), were followed for up to 21 years to detect incident MCI and dementia. PF was assessed at baseline with a composite score and tertiled. Over follow-up, 540 participants underwent autopsies for neuropathological assessment.
resultsCompared to the highest PF, the hazard ratios (95% confidence intervals [CIs]) of the lowest PF were 1.95 (1.43-2.66) for MCI in the cognitively intact group and 1.55 (1.03-2.33) for dementia in the MCI group. Low PF was further related to Alzheimer's disease pathology (odds ratio [OR] 1.32, 95% CI 1.19-1.47) and vascular pathology (OR 3.05, 95% CI 1.49-6.25). DISCUSSION: Low PF increases MCI risk and accelerates MCI progression to dementia. Both neurodegenerative and vascular mechanisms may underlie the PF-dementia association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.