Evidence map›Paper›PMID 35184369›Full record

ArticleThe FEBS journal2022

DRAMing for autophagy.

Alexandre Leytens, Jörn Dengjel

Abstract read
In one paragraph

Article in The FEBS journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Tacrolimus inhibits CVB3-targeted regulation of TFEB by PPP3/calcineurin.Frontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alexandre LeytensDepartment of Biology, University of Fribourg, Switzerland.
Jörn DengjelDepartment of Biology, University of Fribourg, Switzerland.ORCID 0000-0002-9453-4614

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy, a catabolic lysosomal recycling pathway, is often found dysregulated in human diseases. Whereas its prime cell stress-related function is cytoprotection, autophagy has also been linked to the activation of apoptosis and cell death. One group of proteins which participates in the orchestration of autophagy and apoptosis is the family of DRAM proteins. In the current issue of The FEBS Journal, Barthet et al. uncover a compensatory crosstalk between the two newest members of the family, DRAM-4 and DRAM-5, the latter one regulating autophagic activity. Comment on https://doi.org/10.1111/febs.16365.

Indexed as

Membrane ProteinsTumor Suppressor Protein p53ApoptosisAutophagyHumansLysosomesMembrane ProteinsTumor Suppressor Protein p53apoptosisautophagyDRAMDRAM-1DRAM-4DRAM-5p53

Identifiers

PMID35184369
PMCPMC9541391

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.