ArticleMedical physics2022
Technical note: Temperature and concentration dependence of water diffusion in polyvinylpyrrolidone solutions.
Article in Medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Calibration of diffusion MRI measurements using aqueous glycerin phantoms with controlled viscosity.Radiological physics and technology · 2026Article
- The role of diffusion-weighted MRI in biological image-guided radiation therapy: a roadmap.Physics in medicine and biology · 2026Review
- Normalization of temperature effects for quality assurance of quantitative prostate apparent diffusion coefficient imaging across multiple sites.Journal of applied clinical medical physics · 2025Article
- Quantitative evaluation of apparent diffusion coefficient in a large multi-unit institution.Physics and imaging in radiation oncology · 2025Article
- Cross-Scanner Harmonization of AI/DL Accelerated Quantitative Bi-Parametric Prostate MRI.Sensors (Basel, Switzerland) · 2025Article
- Open-source quality assurance for multi-parametric MRI: a diffusion analysis update for the magnetic resonance biomarker assessment software (MR-BIAS).Magma (New York, N.Y.) · 2025Article
- Article
- The QIBA Profile for Diffusion-Weighted MRI: Apparent Diffusion Coefficient as a Quantitative Imaging Biomarker.Radiology · 2024Review
- Technical note: hydrogel-based mimics of prostate cancer with matched relaxation, diffusion and kurtosis for validating multi-parametric MRI.Medical physics · 2024Article
- Time-dependent diffusion tensor imaging and diffusion modeling of age-related differences in the medial gastrocnemius and feasibility study of correlations to histopathology.NMR in biomedicine · 2023Article
- Evaluation of Apparent Diffusion Coefficient Repeatability and Reproducibility for Preclinical MRIs Using Standardized Procedures and a Diffusion-Weighted Imaging Phantom.Tomography (Ann Arbor, Mich.) · 2023Article
- Technical note: Temperature and concentration dependence of water diffusion in polyvinylpyrrolidone solutions.Medical physics · 2022Article
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5 authors.
Funding
Abstract
objectiveThe goal of this work is to provide temperature and concentration calibration of water diffusivity in polyvinylpyrrolidone (PVP) solutions used in phantoms to assess system bias and linearity in apparent diffusion coefficient (ADC) measurements.
methodADC measurements were performed for 40 kDa (K40) PVP of six concentrations (0%, 10%, 20%, 30%, 40%, and 50% by weight) at three temperatures (19.5°C, 22.5°C, and 26.4°C), with internal phantom temperature monitored by optical thermometer (±0.2°C). To achieve ADC measurement and fit accuracy of better than 0.5%, three orthogonal diffusion gradients were calibrated using known water diffusivity at 0°C and system gradient nonlinearity maps. Noise-floor fit bias was also controlled by limiting the maximum b-value used for ADC calculation of each sample. The ADC temperature dependence was modeled by Arrhenius functions of each PVP concentration. The concentration dependence was modeled by quadratic function for ADC normalized by the theoretical water diffusion values. Calibration coefficients were obtained from linear regression model fits.
resultsMeasured phantom ADC values increased with temperature and decreasing PVP concentration, [PVP]. The derived Arrhenius model parameters for [PVP] between 0% and 50%, are reported and can be used for K40 ADC temperature calibration with absolute ADC error within ±0.016 μm
conclusionThe study provides ground-truth ADC values for K40 PVP solutions commonly used in diffusion phantoms for scanning at ambient room temperature. The described procedures and the reported calibration can be used for quality control and standardization of measured ADC values of PVP at different concentrations and temperatures.
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